Evidence map›Paper›PMID 27617398›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2016

Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor.

Bei Tong, Xusheng Yuan, Yannong Dou, Xin Wu, Yuhui Wang, Yufeng Xia, Yue Dai

Open access · bronzeAbstract read
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In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  11. Effect of polycyclic aromatic hydrocarbons on immunity.Journal of translational autoimmunity · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bei TongDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Xusheng YuanDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Yannong DouDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Xin WuDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Yuhui WangDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Yufeng XiaDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Yue DaiDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinomenine (SIN), an anti-arthritis drug, has previously been proven to exert immunomodulatory activity in rats by inducing intestinal regulatory T-cells (Treg cells). Here, we assessed the effect of SIN on the generation and function of Treg cells in autoimmune arthritis, and the underlying mechanisms in view of aryl hydrocarbon receptor (AhR). The proportions of Treg cells and IL-17-producing T-cells (Th17 cells) differentiated from naive T-cells were analyzed by flow cytometric analysis. The AhR agonistic effect of SIN was tested by analyzing the activation of downstream signaling pathways and target genes. The dependence of intestinal Treg cell induction and arthritis alleviation by SIN on AhR activation was confirmed in a mouse collagen-induced arthritis (CIA) model. SIN promoted the differentiation and function of intestinal Treg cells in vitro. It induced the expression and activity of AhR target gene, promoted AhR/Hsp90 dissociation and AhR nuclear translocation, induced XRE reporter activity, and facilitated AhR/XRE binding in vitro, displaying the potential to be an agonist of AhR. In CIA mice, SIN induced the generation of intestinal Treg cells, and facilitated the immunosuppressive function of these Treg cells as shown by an adoptive transfer test. In addition, the induction of intestinal Treg cells and the anti-arthritic effect of SIN in CIA mice could be largely diminished by the AhR antagonist resveratrol. SIN attenuates arthritis by promoting the generation and function of Treg cells in an AhR-dependent manner.

Indexed as

AnimalsAntirheumatic AgentsArthritisCell DifferentiationCytochrome P-450 CYP1A1Lymphocyte ActivationMaleMice, Inbred DBAMorphinansReceptors, Aryl HydrocarbonT-Lymphocytes, RegulatoryAntirheumatic AgentsCytochrome P-450 CYP1A1MorphinansReceptors, Aryl Hydrocarbonsinomenine

Identifiers

PMID27617398
OpenAlexW2519125597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.