Evidence map›Paper›PMID 27617317›Full record

Trial reportInvestigative and clinical urology2016

Tamsulosin versus tadalafil as a medical expulsive therapy for distal ureteral stones: A prospective randomized study.

Hari Bahadur Kc, Anil Shrestha, Ganesh Bhakta Acharya, Robin Bahadur Basnet, Arvind Kumar Shah, Parash Mani Shrestha

Open access · diamondAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Investigative and clinical urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 6 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Pooled it
  6. Tamsulosin vs. Tadalafil as medical expulsive therapy for distal ureteral stones: a systematic review and meta-analysis.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
  7. Trial
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  11. Article
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  15. The effect of phosphodiesterase-5 inhibitor, tadalafil, onIndian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hari Bahadur KcDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Anil ShresthaDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Ganesh Bhakta AcharyaDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Robin Bahadur BasnetDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Arvind Kumar ShahDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Parash Mani ShresthaDepartment of Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Bir Hospital · NPNational Academy of Medical Sciences · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones. MATERIALS AND

methodsThis prospective randomized study was conducted at the Department of Urology of Bir Hospital over a period of 12 months in patients with distal ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups: group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and pain score, analgesic requirements, and adverse drug effects were noted in both groups. Statistical analyses were performed by using Student t-test and chi-square test.

resultsAltogether 85 patients, 41 in group A and 44 in group B, were enrolled in the study. The patients' average age was 31.72±12.63 years, and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and baseline investigations were comparable between the 2 groups. The stone expulsion rate was significantly higher in the tadalafil group than in the tamsulosin group (84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher with tadalafil, this difference was not significant (p=0.099). There were no serious adverse effects.

conclusionsTadalafil has a significantly higher stone expulsion rate than tamsulosin when used as a medical expulsive therapy for distal ureteral stones sized 5-10 mm. Both drugs are safe, effective, and well tolerated with minor side effects.

Indexed as

AdolescentAdultAgedAnalgesics, Non-NarcoticDiclofenacDrug Administration ScheduleFemaleHumansMaleMiddle AgedPain MeasurementProspective StudiesRenal ColicSulfonamidesTadalafilTamsulosinaceclofenacAnalgesics, Non-NarcoticDiclofenacSulfonamidesTadalafilTamsulosinUrological AgentsTadalafilTamsulosinUreteral calculi

Identifiers

PMID27617317
PMCPMC5017565
OpenAlexW2511200276

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.