Evidence map›Paper›PMID 27617308›Full record

ArticleBiochemistry and biophysics reports2016

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.

Kevin A Meyer, Christopher K Neeley, Nicki A Baker, Alexandra R Washabaugh, Carmen G Flesher, Barbara S Nelson, Timothy L Frankel, Carey N Lumeng, Costas A Lyssiotis, Michelle L Wynn and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Glutamine Synthetase as a Therapeutic Target for Cancer Treatment.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kevin A MeyerDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Christopher K NeeleyDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Nicki A BakerDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Alexandra R WashabaughDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Carmen G FlesherUndergraduate Research Opportunity Program, University of Michigan, Ann Arbor, MI, USA.
Barbara S NelsonDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Timothy L FrankelDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA.
Carey N LumengDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA.
Costas A LyssiotisDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Michelle L WynnDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew D RhimDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Robert W O'RourkeDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Targeting hypoxia-inducible mediators to manipulate human adipocyte phenotypeR01DK097449 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'ROURKE, ROBERT W · 2013 to 2017
$1.7M
NCI NIH HHS P30 CA046592NIDDK NIH HHS R01 DK097449
6 · The paper itself

Abstract

Adipocytes promote progression of multiple cancers, but their role in pancreatic intraepithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC) is poorly defined. Nutrient transfer is a mechanism underlying stromal cell-cancer crosstalk. We studied the role of adipocytes in regulating

Indexed as

3T3L1adipocyteglutaminepancreatic cancerpancreatic intraepithelial neoplasia

Identifiers

PMID27617308
PMCPMC5014359
OpenAlexW2414808826

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.