Evidence map›Paper›PMID 27617274›Full record

ArticleGenes & diseases2016

Functional diversity of long non-coding RNAs in immune regulation.

Hua Geng, Xiao-Di Tan

Abstract read
In one paragraph

Article in Genes & diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hua GengCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Xiao-Di TanCenter for Intestinal and Liver Inflammation Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Preservation of mucosal barrier in surgical diseasesR01DK064240 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2004 to 2014
$3.0M
MFG-E8 and progression of alcohol-induced tissue injuryR21AA020494 · NIAAA · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2011 to 2012
$386k
Mechanisms of trauma and hemorrhage-induced impairment of innate immunityI01BX001690 · VA · JESSE BROWN VA MEDICAL CENTER · PI TAN, XIAO-DI · 2013 to 2016
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BLRD VA I01 BX001690NCI NIH HHS P30 CA060553NIAAA NIH HHS R21 AA020494NIDDK NIH HHS R01 DK064240
6 · The paper itself

Abstract

Precise and dynamic regulation of gene expression is a key feature of immunity. In recent years, rapid advances in transcriptome profiling analysis have led to recognize long non-coding RNAs (lncRNAs) as an additional layer of gene regulation context. In the immune system, lncRNAs are found to be widely expressed in immune cells including monocytes, macrophages, dendritic cells (DCs), neutrophils, T cells and B cells during their development, differentiation and activation. However, the functional importance of immune-related lncRNAs is just emerging to be characterized. In this review, we discuss the up-to-date knowledge of lncRNAs in immune regulation.

Identifiers

PMID27617274
PMCPMC5013731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.