ArticleJournal of menopausal medicine2016
Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action.
Article in Journal of menopausal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06497270 (A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Incidence of menopausal symptoms in postmenopausal breast cancer patients treated with aromatase inhibitors.Oncotarget · 2017Pooled it
- Biological Activity of Hops (Nutrients · 2026Review
- Sustainability and Gender Perspective in Food Innovation: Foods and Food Processing Coproducts as Source of Macro- and Micro-Nutrients for Woman-Fortified Foods.Foods (Basel, Switzerland) · 2022Review
- Sleep Disorders and Menopause.Journal of menopausal medicine · 2019Review
- Effect of Foeniculum Vulgare (Fennel) on Sleep Quality of Menopausal Women: A Double-blinded, Randomized Placebo-controlled Trial.Journal of menopausal medicine · 2018Article
- Effect of Fennel on the Health Status of Menopausal Women: A Systematic and Meta-analysis.Journal of menopausal medicine · 2018Article
- Effect of Herbal Medicine on Vaginal Epithelial Cells: A Systematic Review and Meta-analysis.Journal of menopausal medicine · 2018Article
- Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops.Molecules (Basel, Switzerland) · 2018Review
- Effect of Phytoestrogen on Depression and Anxiety in Menopausal Women: A Systematic Review.Journal of menopausal medicine · 2017Article
- Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections: Review Article.Journal of menopausal medicine · 2017Review
- Role Identification ofJournal of menopausal medicine · 2017Review
- Sleep disorder, an independent risk associated with arterial stiffness in menopause.Scientific reports · 2017Article
- Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus.Journal of menopausal medicine · 2017Article
- Beer Polyphenols and Menopause: Effects and Mechanisms-A Review of Current Knowledge.Oxidative medicine and cellular longevity · 2017Review
- Acacia Nilotica: New Plant for Help in Pelvic Organ Prolapse.Journal of menopausal medicine · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Menopause is a critical stage of women's life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms affecting about 50% to 80% of middle-aged women. Obviously, these symptoms, resulting from estrogen deficiency during menopause, can exert negative effects on women's health and quality of life and thus require to be managed through approaches such as hormone replacement therapy (HRT). Many herbal treatments for menopause symptoms contain and its components such as 8-prenylnaringenin, 6-PN, isoxanthohumol and xanthohumol. Recent in-vivo studies have highlighted the ability of 8-prenylnaringenin to reduce serum-luteinizing hormone (LH) and follicle-stimulating hormone (FSH), to increase serum prolactin levels and uterine weight, and to induce vaginal hyperplastic epithelium. Previous research has shown that hops extract can strongly bind to both estrogen receptors, stimulate alkaline phosphatase activity in Ishikawa cells, and upregulate presenelin-2 and progesterone receptor mRNA in Ishikawa cells. Numerous clinical trials have documented significant reductions in the frequency of hot flushes following the administration of hop-containing preparations. Nevertheless, further clinical trials with larger sample size and longer follow-up are warranted to confirm such benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.