Evidence map›Paper›PMID 27617178›Full record

ArticleAdipocyte

Dropping in on the lipid droplet- tumor protein D52 (TPD52) as a new regulator and resident protein.

Yuyan Chen, Sarah Frost, Jennifer A Byrne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Yuyan ChenMolecular Oncology Laboratory; Children's Cancer Research Unit; Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia; The University of Sydney Discipline of Pediatrics and Child Health; The Children's Hospital at Westmead, Westmead, NSW, Australia.
Sarah FrostMolecular Oncology Laboratory; Children's Cancer Research Unit; Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia; The University of Sydney Discipline of Pediatrics and Child Health; The Children's Hospital at Westmead, Westmead, NSW, Australia.
Jennifer A ByrneMolecular Oncology Laboratory; Children's Cancer Research Unit; Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW, Australia; The University of Sydney Discipline of Pediatrics and Child Health; The Children's Hospital at Westmead, Westmead, NSW, Australia.
Children's Hospital at Westmead · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid droplets are essential for both the storage and retrieval of excess cellular nutrients, and their biology is regulated by a diverse range of cellular proteins, some of which function at the lipid droplet. Numerous studies have characterized lipid droplet proteomes in different organisms and cell types, and RNAi whole genome screening studies have examined the genetic regulation of lipid storage in C. elegans and D. melanogaster. While tumor protein D52 (TPD52) did not emerge from earlier studies as a strong candidate, exogenous expression of human TPD52 in cultured cells resulted in significantly increased numbers of lipid droplets, and oleic acid supplementation increased TPD52 detection at both lipid droplets and the Golgi apparatus. These results suggest that direct testing of proteins that are infrequently but recurrently identified in proteomic and RNAi screening studies may identify novel lipid droplet regulators. While the analysis of these possibly lower-abundance or itinerant lipid droplet proteins may be more technically challenging, such proteins could facilitate a more detailed interrogation of emerging aspects of lipid droplet biology.

Indexed as

Golgi apparatuslipid dropletlipogenesisperilipintumor protein D52

Identifiers

PMID27617178
PMCPMC5014004
OpenAlexW2317029302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.