ArticleChemical science2016
Controlling amphiphilic copolymer self-assembly morphologies based on macrocycle/anion recognition and nucleotide-induced payload release.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 43 citations in OpenAlex.
- Dynamic Control of Self-Assembly of Amphiphilic Conjugated Alkenes in Water by Reactions.ACS omega · 2022Article
- "Texas-Sized" Molecular Boxes: From Chemistry to Applications.Molecules (Basel, Switzerland) · 2021Review
- Deciphering the evolution of supramolecular nanofibers in solution and solid-state: a combined microscopic and spectroscopic approach.Chemical science · 2021Article
- Binding Properties and Supramolecular Polymerization of a Water-Soluble Resorcin[4]arene.Organic chemistry frontiers : an international journal of organic chemistry · 2019Article
- pH-Induced Transition Between Single-Chain Macrocyclic Amphiphile and [Frontiers in chemistry · 2019Article
- Cooperative supramolecular polymers with anthracene‒endoperoxide photo-switching for fluorescent anti-counterfeiting.Nature communications · 2018Article
- Dynamic and programmable morphology and size evolution via a living hierarchical self-assembly strategy.Nature communications · 2018Article
- Binding and Selectivity of Essential Amino Acid Guests to the Inverted Cucurbit[7]uril Host.ACS omega · 2017Article
- Stimulus-responsive block copolymer nano-objects and hydrogelsPolymer chemistry · 2017Article
- Using Dynamic Covalent Chemistry To Drive Morphological Transitions: Controlled Release of Encapsulated Nanoparticles from Block Copolymer Vesicles.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
We report here a new approach to creating diversiform copolymer-derived self-assembly morphologies that relies on macrocycle/anion recognition in aqueous media. This approach exploits the anion binding features of a water-soluble form of the so-called 'Texas-sized' molecular box. When this tetracationic receptor is added to an aqueous solution of an amphiphilic copolymer bearing tethered carboxylate anion substituents, binding occurs to form a macrocycle/polymer complex. As the concentration of the box-like receptor increases, the relative hydrophilic fraction of the copolymer complex likewise increases. This leads to changes in the overall morphology of the self-assembled ensemble. The net result is an environmentally controllable system that mimics on a proof-of-concept level the structural evolution of organelles seen in living cells. The macrocycle/anion interactions respond in differing degrees to three key biological species, namely ATP, ADP, and AMP, which may be used as "inputs" to induce disassembly of these vehicles. As a result of this triggering and the nature of the morphological changes induced, the present copolymer system is capable of capturing and releasing in controlled manner various test payloads, including hydrophobic and hydrophilic fluorophores. The copolymer displays low inherent cytotoxicity as inferred from cell proliferation assays involving the HUVEC and HepG2 cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.