ArticleMolecular and cellular endocrinology2017
Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.
Article in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Gene Misexpression in aJournal of the Endocrine Society · 2024Article
- The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Noonan syndrome: rhGH treatment and PTPN11 mutation.Molecular genetics & genomic medicine · 2023Article
- Hypothalamic control of energy expenditure and thermogenesis.Experimental & molecular medicine · 2022Review
- Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencing.Frontiers in endocrinology · 2022Review
- ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.Cell death & disease · 2021Article
- Whole-genome SNP markers reveal conservation status, signatures of selection, and introgression in Chinese Laiwu pigs.Evolutionary applications · 2021Article
- Selective effects of protein 4.1N deficiency on neuroendocrine and reproductive systems.Scientific reports · 2020Article
- PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression.Endocrinology · 2020Article
- SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells.Stem cell reports · 2019Article
- SOXopathies: Growing Family of Developmental Disorders Due to SOX Mutations.Trends in genetics : TIG · 2019Review
- Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators.Nature communications · 2019Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The hypothalamic-pituitary axes are the coordinating centers for multiple endocrine gland functions and physiological processes. Defects in the hypothalamus or pituitary gland can cause reduced growth and severe short stature, affecting approximately 1 in 4000 children, and a large percentage of cases of pituitary hormone deficiencies do not have an identified genetic cause. SOX21 is a protein that regulates hair, neural, and trophoblast stem cell differentiation. Mice lacking Sox21 have reduced growth, but the etiology of this growth defect has not been described. We studied the expression of Sox21 in hypothalamic-pituitary development and examined multiple endocrine axes in these mice. We find no evidence of reduced intrauterine growth, food intake, or physical activity, but there is evidence for increased energy expenditure in mutants. In addition, despite changes in pituitary hormone expression, hypothalamic-pituitary axes appear to be functional. Therefore, SOX21 variants may be a cause of non-endocrine short stature in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.