Evidence map›Paper›PMID 27616659›Full record

ArticleCell calcium2016

Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: Evidence from cyclophilin D knockout mice.

Richard Gordan, Nadezhda Fefelova, Judith K Gwathmey, Lai-Hua Xie

Open access · greenAbstract read
In one paragraph

Article in Cell calcium, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. MCU-i4, a mitochondrial CaOncology research · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Anshen Buxin Liuwei Pill, a Mongolian Medicinal Formula, Could Protect HEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Review
  8. Excitation-contraction coupling and calcium release in atrial muscle.Pflugers Archiv : European journal of physiology · 2021
    Review
  9. Article
  10. Article
  11. Mitochondrial calcium uniporter complex activation protects against calcium alternans in atrial myocytes.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Pharmacological Modulation of Mitochondrial CaFrontiers in physiology · 2018
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Richard GordanDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Nadezhda FefelovaDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Judith K GwathmeyDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Lai-Hua XieDepartment of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA. Electronic address: xiela@njms.rutgers.edu.
Rutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
Antiarrhythmic Mechanisms in the Hearts of Hibernating MammalsR01HL097979 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI XIE, LAI-HUA · 2010 to 2015
$1.9M
NHLBI NIH HHS R01 HL097979NHLBI NIH HHS R01 HL133294
6 · The paper itself

Abstract

In the present study, we have used a genetic mouse model that lacks cyclophilin D (CypD KO) to assess the cardioprotective effect of mitochondrial permeability transition pore (mPTP) inhibition on Ca

Indexed as

AnimalsArrhythmias, CardiacCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCyclophilinsDose-Response Relationship, DrugMembrane Potential, MitochondrialMiceMice, KnockoutMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocytes, CardiacPeptidyl-Prolyl Isomerase FStructure-Activity RelationshipCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCyclophilinsMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FPPIF protein, mouseArrhythmiasCalciumCyclophilin DHeartMitochondriamPTP

Identifiers

PMID27616659
PMCPMC5127715
OpenAlexW2515821642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.