ArticleNeuroImage2016
Functional magnetic resonance imaging of the cervical spinal cord during thermal stimulation across consecutive runs.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.NeuroImage. Clinical · 2019Trial
- Test-Retest Reliability of Sensorimotor Activity Measured With Spinal Cord fMRI.Human brain mapping · 2026Article
- Spatial distribution of spinal cord fMRI activity with electrocutaneous stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Spatial distribution of spinal cord fMRI activity with electrocutaneous stimulation.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- CoSpine open access simultaneous cortico-spinal fMRI database of thermal pain and motor tasks.Scientific data · 2025Article
- Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study.bioRxiv : the preprint server for biology · 2025Article
- Data-driven denoising in spinal cord fMRI with principal component analysis.bioRxiv : the preprint server for biology · 2025Article
- EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla.Human brain mapping · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional magnetic resonance imaging of the lumbosacral cord during a lower extremity motor task.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Recent developments and future avenues for human corticospinal neuroimaging.Frontiers in human neuroscience · 2024Review
- Automatic segmentation of the spinal cord nerve rootlets.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spinal Cord fMRI: A New Window into the Central Nervous System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- When cooling of the skin is perceived as warmth: Enhanced paradoxical heat sensation by pre-cooling of the skin in healthy individuals.Temperature (Austin, Tex.) · 2023Article
- Beyond pain in the brain: A clinician's guide to interpreting the spinal cord's role in the pain experience.Musculoskeletal science & practice · 2022Article
- Effects of variability in manually contoured spinal cord masks on fMRI co-registration and interpretation.Frontiers in neurology · 2022Article
- Article
- Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions?The Journal of orthopaedic and sports physical therapy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The spinal cord is the first site of nociceptive processing in the central nervous system and has a role in the development and perpetuation of clinical pain states. Advancements in functional magnetic resonance imaging are providing a means to non-invasively measure spinal cord function, and functional magnetic resonance imaging may provide an objective method to study spinal cord nociceptive processing in humans. In this study, we tested the validity and reliability of functional magnetic resonance imaging using a selective field-of-view gradient-echo echo-planar-imaging sequence to detect activity induced blood oxygenation level-dependent signal changes in the cervical spinal cord of healthy volunteers during warm and painful thermal stimulation across consecutive runs. At the group and subject level, the activity was localized more to the dorsal hemicord, the spatial extent and magnitude of the activity was greater for the painful stimulus than the warm stimulus, and the spatial extent and magnitude of the activity exceeded that of a control analysis. Furthermore, the spatial extent of the activity for the painful stimuli increased across the runs likely reflecting sensitization. Overall, the spatial localization of the activity varied considerably across the runs, but despite this variability, a machine-learning algorithm was able to successfully decode the stimuli in the spinal cord based on the distributed pattern of the activity. In conclusion, we were able to successfully detect and characterize cervical spinal cord activity during thermal stimulation at the group and subject level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.