ArticleScientific reports2016
Discovery of novel xylosides in co-culture of basidiomycetes Trametes versicolor and Ganoderma applanatum by integrated metabolomics and bioinformatics.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 55 citations in OpenAlex.
- Application of Metabolomics in the Exploration of Bioactive Compounds and Drug Development from Medicinal Fungi.Metabolites · 2026Review
- Effects of Co-Cultivation on the Phenolic Composition and Bioactive Properties of Basidiomycete Mycelia: Antioxidant, Photoprotective, Anti-Tyrosinase, and In Silico Evidence.Molecules (Basel, Switzerland) · 2026Article
- Optimization of sporulation of Trametes sanguinea ZHSJ and untargeted metabolomics of spores, mycelium and fruiting body.Scientific reports · 2026Article
- Metabolomic profiling and antimicrobial investigation ofNarra J · 2025Article
- Regulation and induction of fungal secondary metabolites: a comprehensive review.Archives of microbiology · 2025Review
- Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass.Journal of fungi (Basel, Switzerland) · 2025Review
- Current Approaches and Implications in Discovery of Novel Bioactive Products from Microbial Sources.Current microbiology · 2025Review
- Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans.Natural products and bioprospecting · 2025Article
- Natural and engineered xylosyl products from microbial source.Natural products and bioprospecting · 2024Review
- Optimization of polysaccharide conditions and analysis of antioxidant capacity in the co-culture ofPeerJ · 2024Article
- Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum fromProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- The Potential Use of Fungal Co-Culture Strategy for Discovery of New Secondary Metabolites.Microorganisms · 2023Review
- Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective.Microbial cell factories · 2023Review
- Enhancing chemical and biological diversity by co-cultivation.Frontiers in microbiology · 2023Review
- DNA Authentication and Chemical Analysis ofApplied and environmental microbiology · 2022Article
- Application of Metabolomics in Fungal Research.Molecules (Basel, Switzerland) · 2022Review
- How to Completely Squeeze a Fungus-Advanced Genome Mining Tools for Novel Bioactive Substances.Pharmaceutics · 2022Review
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
- Solid-state co-culture fermentation of simulated food waste with filamentous fungi for production of bio-pigments.Applied microbiology and biotechnology · 2022Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptomic analysis of cultured fungi suggests that many genes for secondary metabolite synthesis are presumably silent under standard laboratory condition. In order to investigate the expression of silent genes in symbiotic systems, 136 fungi-fungi symbiotic systems were built up by co-culturing seventeen basidiomycetes, among which the co-culture of Trametes versicolor and Ganoderma applanatum demonstrated the strongest coloration of confrontation zones. Metabolomics study of this co-culture discovered that sixty-two features were either newly synthesized or highly produced in the co-culture compared with individual cultures. Molecular network analysis highlighted a subnetwork including two novel xylosides (compounds 2 and 3). Compound 2 was further identified as N-(4-methoxyphenyl)formamide 2-O-β-D-xyloside and was revealed to have the potential to enhance the cell viability of human immortalized bronchial epithelial cell line of Beas-2B. Moreover, bioinformatics and transcriptional analysis of T. versicolor revealed a potential candidate gene (GI: 636605689) encoding xylosyltransferases for xylosylation. Additionally, 3-phenyllactic acid and orsellinic acid were detected for the first time in G. applanatum, which may be ascribed to response against T.versicolor stress. In general, the described co-culture platform provides a powerful tool to discover novel metabolites and help gain insights into the mechanism of silent gene activation in fungal defense.
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