ArticleScientific reports2016
Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Current therapeutic interventions combating biofilm-related infections in orthopaedics : a systematic review of in vivo animal studies.Bone & joint research · 2022Pooled it
- Pooled it
- Optimization of sampling protocol, specimen types, and sampling sites in periprosthetic joint infections: a retrospective study.Journal of orthopaedic surgery and research · 2026Article
- Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model.Journal of orthopaedic surgery and research · 2024Article
- Material-based treatment strategies against intraosseous implant biofilm infection.Biochemistry and biophysics reports · 2024Review
- Cutibacterium acnes biofilm formation is influenced by bone microenvironment, implant surfaces and bacterial internalization.BMC microbiology · 2024Article
- Article
- The Effect of Early Cultures and Dual-port Expanders on Two-stage, Prepectoral Breast Reconstruction: The 25/25 Study.Plastic and reconstructive surgery. Global open · 2024Article
- Article
- The First Case of Prosthesis-related Infection Caused byAnnals of laboratory medicine · 2022Article
- An ionic silver coating prevents implant-associated infection by anaerobic bacteria in vitro and in vivo in mice.Scientific reports · 2022Article
- Skeletal infections: microbial pathogenesis, immunity and clinical management.Nature reviews. Microbiology · 2022Review
- Delayed perihepatic abscess caused byBMJ case reports · 2022Article
- A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles ofFrontiers in microbiology · 2021Review
- High Prevalence of Biofilms on Retrieved Implants from Aseptic Pseudarthrosis Cases.Spine surgery and related research · 2021Article
- Is Implant Coating With Tyrosol- and Antibiotic-loaded Hydrogel Effective in Reducing Cutibacterium (Propionibacterium) acnes Biofilm Formation? A Preliminary In Vitro Study.Clinical orthopaedics and related research · 2019Article
- Cutibacterium (formerly Propionibacterium) acnes clavicular infection.Journal of bone and joint infection · 2019Article
- Growth of Cutibacterium acnes is common on osteosynthesis material of the shoulder in patients without signs of infection.Acta orthopaedica · 2018Article
- Article
- Three cases of metallosis associated with spine instrumentation.Journal of materials science. Materials in medicine · 2017Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether Propionibacterium acnes (P. acnes) causes surgical-site infections (SSI) after orthopedic surgery is controversial. We previously reported that we frequently find P. acnes in intraoperative specimens, yet none of the patients have clinically apparent infections. Here, we tracked P. acnes for 6 months in a mouse osteomyelitis model. We inoculated P. acnes with an implant into the mouse femur in the implant group; the control group was treated with the bacteria but no implant. We then observed over a 6-month period using optical imaging system. During the first 2 weeks, bacterial signals were detected in the femur in the both groups. The bacterial signal completely disappeared in the control group within 28 days. Interestingly, in the implant group, bacterial signals were still present 6 months after inoculation. Histological and scanning electron-microscope analyses confirmed that P. acnes was absent from the control group 6 months after inoculation, but in the implant group, the bacteria had survived in a biofilm around the implant. PCR analysis also identified P. acnes in the purulent effusion from the infected femurs in the implant group. To our knowledge, this is the first report showing that P. acnes causes SSI only in the presence of an implant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.