ArticleScientific reports2016
Phase correlation imaging of unlabeled cell dynamics.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Label-free in-line characterization of immune cell culture using quantitative phase imaging.NPJ Regenerative medicine · 2025Article
- Rapid mechanical phenotyping of breast cancer cells based on stochastic intracellular fluctuations.iScience · 2024Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Review
- Functional imaging with dynamic quantitative oblique back-illumination microscopy.Journal of biomedical optics · 2022Article
- Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cycle.Scientific reports · 2022Article
- Quantitative imaging of Caenorhabditis elegans dauer larvae during cryptobiotic transition.Biophysical journal · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust against Strong Perturbation.Biophysical journal · 2020Article
- Cell viscoelasticity is linked to fluctuations in cell biomass distributions.Scientific reports · 2020Article
- Article
- Ptychographic imaging of NaD1 induced yeast cell death.Biomedical optics express · 2019Article
- Measurements on ATP induced cellular fluctuations using real-time dual view transport of intensity phase microscopy.Biomedical optics express · 2019Article
- Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm.Nature communications · 2019Article
- Fourier phase based depth-resolved nanoscale nuclear architecture mapping for cancer detection.Methods (San Diego, Calif.) · 2018Review
- Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography.Biomedical optics express · 2017Article
- Quantitative assessment of neural outgrowth using spatial light interference microscopy.Journal of biomedical optics · 2017Article
- 3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
We present phase correlation imaging (PCI) as a novel approach to study cell dynamics in a spatially-resolved manner. PCI relies on quantitative phase imaging time-lapse data and, as such, functions in label-free mode, without the limitations associated with exogenous markers. The correlation time map outputted in PCI informs on the dynamics of the intracellular mass transport. Specifically, we show that PCI can extract quantitatively the diffusion coefficient map associated with live cells, as well as standard Brownian particles. Due to its high sensitivity to mass transport, PCI can be applied to studying the integrity of actin polymerization dynamics. Our results indicate that the cyto-D treatment blocking the actin polymerization has a dominant effect at the large spatial scales, in the region surrounding the cell. We found that PCI can distinguish between senescent and quiescent cells, which is extremely difficult without using specific markers currently. We anticipate that PCI will be used alongside established, fluorescence-based techniques to enable valuable new studies of cell function.
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Registered trials
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