Evidence map›Paper›PMID 2761544›Full record

ArticleMolecular and cellular biology1989

Expression of the poly(A)-binding protein during development of Xenopus laevis.

B D Zelus, D H Giebelhaus, D W Eib, K A Kenner, R T Moon

Abstract read
In one paragraph

Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Review
  3. Manipulation of gene function in Xenopus laevis.Methods in molecular biology (Clifton, N.J.) · 2011
    Article
  4. Article
  5. Article
  6. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.Proceedings of the National Academy of Sciences of the United States of America · 2005
    Article
  7. Article
  8. Translational control by CPEB: a means to the end.Nature reviews. Molecular cell biology · 2001
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cytoplasmic polyadenylation in development and beyond.Microbiology and molecular biology reviews : MMBR · 1999
    Review
  15. A poly(A) binding protein functions in the chloroplast as a message-specific translation factor.Proceedings of the National Academy of Sciences of the United States of America · 1998
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

B D ZelusDepartment of Pharmacology, School of Medicine, University of Washington, Seattle 98915.
D H Giebelhaus
D W Eib
K A Kenner
R T Moon
University of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
SPECTRIN SYNTHESIS AND ASSEMBLY IN TRANSFECTED CELLSR01DK035774 · NIDDK · UNIVERSITY OF WASHINGTON · PI MOON, RANDALL TODD · 1987 to 1989
–
NIDDK NIH HHS DK35774NIGMS NIH HHS 5 T32 GM07270
6 · The paper itself

Abstract

We have isolated and sequenced cDNA clones encoding the poly(A)-binding protein of Xenopus laevis oocytes. Polyclonal antiserum was raised against a fusion protein encoding 185 amino acids of the Xenopus poly(A)-binding protein. This antiserum localizes the poly(A)-binding protein to subcellular sites associated with protein synthesis; in the retina, immunoreactive protein is detected in the synthetically active inner segment of the photoreceptor but not in the transductive outer segment. Transcripts encoding the poly(A)-binding protein are present in oocytes, although no protein is detected on protein blots. In contrast, the levels of both transcripts and protein increase in development, which correlates with the observed increase in total poly(A) during Xenopus embryogenesis (N. Sagata, K. Shiokawa, and K. Yamana, Dev. Biol. 77:431-448, 1980).

Indexed as

Amino Acid SequenceAnimalsBase SequenceCarrier ProteinsCell DifferentiationCodonDNADNA ProbesElectrophoresis, Gel, Two-DimensionalGene Expression RegulationMolecular Sequence DataOocytesPoly APoly(A)-Binding ProteinsRabbitsRetinaCarrier ProteinsCodonDNADNA ProbesPoly APoly(A)-Binding ProteinsRNA, Messenger

Identifiers

PMID2761544
PMCPMC362352
OpenAlexW1784570168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.