ArticleScientific reports2016
Endothelial dysfunction correlates with decompression bubbles in rats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Circulating Bubbles in Decompression Sickness: Pathophysiology and Experimental Models.Biomolecules · 2026Review
- Therapeutic Potential of GYY4137 in Reducing Oxidative Stress and Mortality in Experimental Decompression Sickness.Scientific reports · 2026Article
- NOX2 inhibition attenuates oxidative stress and eNOS uncoupling in pulmonary arteries of rats following simulated air diving.PloS one · 2026Article
- Hyperbaric oxygen pretreatment on endothelial cell injury via heat shock factor 1 in decompression sickness.Frontiers in molecular biosciences · 2025Article
- A review of nutritional recommendations for scuba divers.Journal of the International Society of Sports Nutrition · 2024Review
- Decompression illness: a comprehensive overview.Diving and hyperbaric medicine · 2024Article
- Decompression sickness-induced skeletal muscle injury: an animal model and pathological analysis.Frontiers in veterinary science · 2024Article
- Retinal Layer and Choroidal Changes in Deep and Scuba Divers: Evidence of Pachychoroid Spectrum-Like Findings.Journal of ophthalmology · 2024Article
- Effect of angiotensin II on irradiation exacerbated decompression sickness.Scientific reports · 2023Article
- Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies.Frontiers in immunology · 2023Review
- Biomarkers related to gas embolism: Gas score, pathology, and gene expression in a gas bubble disease model.PloS one · 2023Article
- Establishment of a fish model to study gas-bubble lesions.Scientific reports · 2022Article
- Analysis of the Increase of Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression and the Effect of Exposure in a Hyperbaric Chamber on VCAM-1 in Human Blood Serum: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2022Article
- Human Physiological Responses to a Single Deep Helium-Oxygen Diving.Frontiers in physiology · 2021Article
- MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats.Frontiers in physiology · 2021Article
- Decompressive Pathology in Cetaceans Based on an Experimental Pathological Model.Frontiers in veterinary science · 2021Article
- Acute Effects on the Human Peripheral Blood Transcriptome of Decompression Sickness Secondary to Scuba Diving.Frontiers in physiology · 2021Article
- Endothelial Injury in Diving: Atomic Force-, Electronic-, and Light-Microscopy Study of the Ovine Decompressed Blood Vessels.Frontiers in physiology · 2021Article
- Severe Decompression Sickness Associated with Shock and Acute Respiratory Failure.Case reports in critical care · 2020Article
- Biphasic effects of autophagy on decompression bubble-induced endothelial injury.Journal of cellular and molecular medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow and three rapid. Bubble formation was detected ultrasonically following decompression for two hours, before measurement of endothelial related indices. Bubbles were found in only rapid-decompressed rats and the amount correlated with decompression rate with significant variability. Serum levels of ET-1, 6-keto-PGF1α, ICAM-1, VCAM-1 and MDA, lung Wet/Dry weight ratio and histological score increased, serum NO decreased following rapid decompression. Endothelial-dependent vasodilatation to Ach was reduced in pulmonary artery rings among rapid-decompressed rats. Near all the above changes correlated significantly with bubble amounts. The results suggest that bubbles may be the causative agent of decompression-induced endothelial damage and bubble amount is of clinical significance in assessing decompression stress. Furthermore, serum levels of ET-1 and MDA may serve as sensitive biomarkers with the capacity to indicate endothelial dysfunction and decompression stress following dives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.