Evidence map›Paper›PMID 27614961›Full record

ArticleLung2016

Inhaled Vitamin D: A Novel Strategy to Enhance Neonatal Lung Maturation.

Sneha K Taylor, Reiko Sakurai, Tokusho Sakurai, Virender K Rehan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sneha K TaylorDepartment of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA.
Reiko SakuraiDepartment of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA.
Tokusho SakuraiDepartment of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA.
Virender K RehanDepartment of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA. vrehan@labiomed.org.

Funding

Developmental Nicotine Exposure & Transgenerationally Altered Lung PhenotypeR01HL127237 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2016 to 2019
$1.8M
Fibroblast Cell Signaling in Utero Nicotine-Induced Lung InjuryR01HD051857 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2008 to 2012
$1.7M
Molecular Basis of Childhood Asthma Following Perinatal Vitamin D DeficiencyR21HL107118 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2011 to 2012
$377k
In Utero Nicotine Exposure & Transgenerational Transmission of AsthmaR21HD071731 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2012 to 2013
$369k
A Molecular Approach to Prevent Pulmonary Dysfunction in the Intrauterine GrowthR03HD058948 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2009 to 2010
$137k
NHLBI NIH HHS R01 HL127237NHLBI NIH HHS R21 HL107118NICHD NIH HHS R01 HD051857NICHD NIH HHS R03 HD058948NICHD NIH HHS R21 HD071731
6 · The paper itself

Abstract

introductionThe physiologic vitamin D (VD), 1α,25(OH)

methodsOne-day-old rat pups were administered three different doses of 1,25D and its physiologic precursor 25(OH)D (25D), or the diluent, via nebulization daily for 14 days. Pups were sacrificed for lung, kidneys, and blood collection to determine markers of lung maturation, and serum 25D and calcium levels.

resultsCompared to controls, nebulized 25D and 1,25D enhanced lung maturation as evidenced by the increased expression of markers of alveolar epithelial (SP-B, leptin receptor), mesenchymal (PPARγ, C/EBPα), and endothelial (VEGF, FLK-1) differentiation, surfactant phospholipid synthesis, and lung morphology without any significant increases in serum 25D and calcium levels.

conclusionsInhaled VD is a potentially safe and effective novel strategy to enhance neonatal lung maturation.

Indexed as

Administration, InhalationAlveolar Epithelial CellsAnimalsCalcitriolCalciumCCAAT-Enhancer-Binding Protein-alphaCell DifferentiationCholineEndotheliumLungMesodermPPAR gammaPulmonary Surfactant-Associated Protein BRatsRats, Sprague-DawleyReceptors, Calcitriol25-hydroxyvitamin DCalcitriolCalciumCCAAT-Enhancer-Binding Protein-alphaCholinePPAR gammaPPAR gamma, ratPulmonary Surfactant-Associated Protein BReceptors, CalcitriolReceptors, LeptinTrioleinVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratVascular Endothelial Growth Factor Receptor-2Vitamin DVitaminsActive vitamin DBronchopulmonary dysplasiaChildhood asthmaLung developmentPrematurity

Identifiers

PMID27614961
PMCPMC5191914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.