Trial reportPsychopharmacology2016
Oxytocin modulates hemodynamic responses to monetary incentives in humans.
Trial report in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Oxytocin differentially modulates reward system responses to social and non-social incentives.Psychopharmacology · 2025Trial
- L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others.Psychopharmacology · 2024Trial
- Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Assessment of Reward-Related Brain Function After a Single Dose of Oxytocin in Autism: A Randomized Controlled Trial.Biological psychiatry global open science · 2022Article
- Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial.Frontiers in child and adolescent psychiatry · 2022Article
- Altered Reward Processing and Sex Differences in Chronic Pain.Frontiers in neuroscience · 2022Article
- Oxytocin Facilitates Self-Serving Rather Than Altruistic Tendencies in Competitive Social Interactions Via Orbitofrontal Cortex.The international journal of neuropsychopharmacology · 2019Article
- Neuropeptide Y and representation of salience in human nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Dissociable Neural Responses to Monetary and Social Gain and Loss in Women With Major Depressive Disorder.Frontiers in behavioral neuroscience · 2019Article
- Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward.Neuroscience and biobehavioral reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleOxytocin is a neuropeptide widely recognized for its role in regulating social and reproductive behavior. Increasing evidence from animal models suggests that oxytocin also modulates reward circuitry in non-social contexts, but evidence in humans is lacking.
objectivesWe examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task.
methodsThe blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin.
resultsWe found that oxytocin increases the BOLD signal in the midbrain (substantia nigra and ventral tegmental area) during the late phase of the hemodynamic response to incentive stimuli. Oxytocin's effects on midbrain responses correlated positively with its effects on positive emotional state. We did not detect an effect of oxytocin on responses in the nucleus accumbens. Whole-brain analyses revealed that oxytocin attenuated medial prefrontal cortical deactivation specifically during anticipation of loss.
conclusionsOur findings demonstrate that intranasal administration of oxytocin modulates human midbrain and medial prefrontal function during motivated behavior. These findings suggest that endogenous oxytocin is a neurochemical mediator of reward behaviors in humans-even in a non-social context-and that the oxytocinergic system is a potential target of pharmacotherapy for psychiatric disorders that involve dysfunction of reward circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.