ArticleInfection2017
Parents as source of pertussis transmission in hospitalized young infants.
Article in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Pertussis-A Re-Emerging Threat Despite Immunization: An Analysis of Vaccine Effectiveness and Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Sources and clinical characteristics of infant pertussis in China: increasing contribution of siblings.BMC infectious diseases · 2025Article
- Laboratory, epidemiological and clinical characteristics of pertussis in children and close contacts: a cross-sectional study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Trend of pathogens and respiratory co-infections in the province of Messina: from pediatric age to senescence.Journal of preventive medicine and hygiene · 2024Article
- Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- [Epidemiological profile of pertussis in infants in Casablanca from 2012 to 2019].The Pan African medical journal · 2023Article
- Experience and attitudes on vaccinations recommended during pregnancy: survey on an Italian sample of women and consultant gynecologists.Human vaccines & immunotherapeutics · 2022Article
- Sero-Epidemiological Study ofVaccines · 2022Article
- Clinical characteristics of 967 children with pertussis: a single-center analysis over an 8-year period in Beijing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Bordetella pertussis in School-Age Children, Adolescents and Adults: A Systematic Review of Epidemiology and Mortality in Europe.Infectious diseases and therapy · 2021Review
- AsymptomaticeLife · 2021Observational
- Pertussis in Italy: how to protect the "unprotectable"?Human vaccines & immunotherapeutics · 2021Observational
- Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study.BMC pediatrics · 2021Article
- AsymptomaticmedRxiv : the preprint server for health sciences · 2020Article
- Pertussis immunization in healthcare workers working in pediatric settings: Knowledge, Attitudes and Practices (KAP) of Occupational Physicians. Preliminary results from a web-based survey (2017).Journal of preventive medicine and hygiene · 2020Article
- Neonatal Immunity toJournal of immunology research · 2019Review
- Prevention of pertussis: from clinical trials to Real World Evidence.Journal of preventive medicine and hygiene · 2018Article
- Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.The Journal of clinical investigation · 2018Article
- Hexavalent vaccines: characteristics of available products and practical considerations from a panel of Italian experts.Journal of preventive medicine and hygiene · 2018Article
- Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization.Human vaccines & immunotherapeutics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies that could be integrated in pertussis control.
methodsThe seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) and prolonged cough symptoms were evaluated in parents of 55 infants aged <6 months hospitalized for confirmed pertussis. Parents of 33 infants with lower respiratory tract infection (LRTI) and parents of 57 healthy infants admitted as outpatients for hip ultrasound examination (HE) were enrolled as controls.
resultsParents of pertussis cases had PT-IgG levels significantly higher as compared to LRTI and HE parents. More than 40 % were compatible as transmitters of pertussis to their babies, since they had a level of PT-IgG ≥ 100 IU/ml, which is considered diagnostic for a recent pertussis episode. Based on serology, the percentage of pertussis cases that had at least one parent as source of infection was 49.1 %. When cough symptoms were taken into account, the percentage of parents putative transmitters of the infection to their infants increased to 56.4 %.
conclusionsParents are scarcely aware of the household transmission of pertussis to their newborns. Our study highlights the need to advise parents about the likelihood of transmission to the newborn and to be particularly aware of coughing symptoms in the household. Since infection can be asymptomatic, a serological survey of family members should also be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.