Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.
Sanjay Varikuti, Gayathri Natarajan, Steve Oghumu, Rachel H Sperling, Ellen Moretti, James Stock, Tracey L Papenfuss, Abhay R Satoskar
Article in Cellular immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 2 institutions in 1 country.
Sanjay VarikutiDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Gayathri NatarajanDepartment of Microbiology, The Ohio State University, Columbus, OH, USA.
Steve OghumuCollege of Public Health, The Ohio State University, Columbus, OH, USA.
Rachel H SperlingDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Ellen MorettiDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
James StockDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Tracey L PapenfussCollege of Veterinary Medicine, The Ohio State University Medical Center, Columbus, USA.
Abhay R SatoskarDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Department of Microbiology, The Ohio State University, Columbus, OH, USA. Electronic address: abhay.satoskar@osumc.edu.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US
Funding
Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
Development of novel therapeutics for a neglected tropical disease leishmaniasisRC4AI092624 · NIAID · OHIO STATE UNIVERSITY · PI KINGHORN, ALAN DOUGLAS, SATOSKAR, ABHAY R · 2010 to 2010
$2.6M
Treatment of cutaneous leishmaniasis using Pentalinon andrieuxii root extractR21AT004160 · NCCIH · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2009 to 2010
$411k
Visualization of CXCR3 allelic usage in vivoR03AI090231 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2010 to 2011
$242k
Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapyR34AI100789 · NIAID · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2012 to 2012
$229k
Chemopreventition and treatment of non-melanoma skin cancer by targeting MIFR03CA164399 · NCI · OHIO STATE UNIVERSITY · PI SATOSKAR, ABHAY R · 2012 to 2013
The outcome of visceral leishmaniasis, caused by parasite Leishmania donovani, depends on the recruitment of leishmanicidal Th1 cells. Chemokine receptor CXCR3, preferentially expressed by Th1 cells, is critical for migration of these T cells during infection. During chronic VL, there is a decrease in the presence of CXCR3-expressing CD4
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis. · full record | OpenQuestion