Evidence map›Paper›PMID 27614631›Full record

ArticleJournal of assisted reproduction and genetics2016

Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women.

Nathalie Zamagni Bessa, Daniela de Oliveira Francisco, Marina de Paula Andres, Bárbara Yasmim Gueuvoghlanian-Silva, Sergio Podgaec, Cintia Fridman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nathalie Zamagni BessaDepartment of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil.
Daniela de Oliveira FranciscoDepartment of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil.
Marina de Paula AndresDepartment of Obstetrics and Gynecology, Clinics Hospital, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 10th floor, Cerqueira Cesar, CEP: 05403-010, São Paulo, SP, Brazil.
Bárbara Yasmim Gueuvoghlanian-SilvaJewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi, CEP: 05652-900, Sao Paulo, SP, Brazil.
Sergio PodgaecDepartment of Obstetrics and Gynecology, Clinics Hospital, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 10th floor, Cerqueira Cesar, CEP: 05403-010, São Paulo, SP, Brazil.
Cintia FridmanDepartment of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil. cfridman@usp.br.ORCID http://orcid.org/0000-0003-2430-4888
Universidade de São Paulo · BRHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.

methodsWe genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.

resultsNo significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism.

conclusionThis study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.

Indexed as

Genetic Association StudiesAdultBrazilEndometriosisFemaleGenetic Predisposition to DiseaseGenotypeHumansIntercellular Adhesion Molecule-1Interleukin-6Polymorphism, Single NucleotideRisk FactorsIL6 protein, humanIntercellular Adhesion Molecule-1Interleukin-6Brazilian populationEndometriosisIntercellular adhesion molecule-1Interleukin-6Polymorphism

Identifiers

PMID27614631
PMCPMC5125152
OpenAlexW2512424707

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.