ArticleFish physiology and biochemistry2017
Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri.
Article in Fish physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri.Biogerontology · 2023Article
- Administration of krill oil extends lifespan of fish Nothobranchius guentheri via enhancement of antioxidant system and suppression of NF-κB pathway.Fish physiology and biochemistry · 2022Article
- Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway.Biogerontology · 2022Article
- Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production.Biogerontology · 2022Article
- The Effect of Meclofenoxate on the Transcriptome of Aging Brain ofInternational journal of molecular sciences · 2022Article
- Biomarkers of oxidative stress in the post-embryonic characterization of the neotropical annual killifish.Biogerontology · 2021Article
- Some Aspects of Development and Histological Structure of the Visual System of Nothobranchius Guentheri.Animals : an open access journal from MDPI · 2021Article
- De Novo Transcriptome Profiling of Brain Tissue from the Annual KillifishLife (Basel, Switzerland) · 2021Article
- Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells.BMC complementary medicine and therapies · 2021Article
- Combined pre-conditioning with salidroside and hypoxia improves proliferation, migration and stress tolerance of adipose-derived stem cells.Journal of cellular and molecular medicine · 2020Article
- Recent Advances in the Systems Biology of Aging.Antioxidants & redox signaling · 2018Review
- Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fishOncotarget · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging asymmetry is the observation that different tissues age in different ways and at different rates. This has not been assessed in a single organism using multiple biomarkers of aging. Here we clearly demonstrated that the levels of protein oxidation and lipid peroxidation as well as CAT, SOD and GPX activities all showed a tissue-dependent change with advancing age; and DNA repair ability, as revealed by the expression of ercc1 and its protein levels, also exhibited a tissue-specific variation with age. We also found that protein oxidation and lipid peroxidation levels remained relatively stable in the liver, intestine, skin and testis as well as in the brain, eye and heart of young, adult and aged fishes; SOD and GPX activities displayed little variation in the intestine, eye and skin as well as in the brain and skin of young, adult and aged fishes; and low and stable expression of ercc1 was observed in the spleen, eye and heart of young, adult and aged fishes. Collectively, these results indicate that aging is tissue specific and asymmetric in N. guentheri. The observation of aging asymmetry may have practical implications for the application of non-intrusion intervention approaches to prolong lifespan.
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