ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2016
Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 51 citations in OpenAlex.
- Mixed-Ligand Complex Formation in the Systems Containing the Potential Drug [VIVO(acac)2] with Blood and Cellular Bioligands. Implications on the Active Species Formed in the Organism.Inorganic chemistry · 2026Article
- Potential Activity of Non-Platinum Metal-Based Organic Complexes Against Different Cancer Cell Types.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Bisphenol A suppresses colon epithelial cell responses via GScientific reports · 2025Article
- Oxidative damage and cell cycle delay induced by vanadium(III) in human peripheral blood cells.Toxicology reports · 2024Article
- Dietary supplementation with N-acetyl-L-cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs.Journal of animal science and biotechnology · 2024Article
- Trace elements in pancreatic cancer.Cancer medicine · 2024Review
- The Deficits of Insulin Signal in Alzheimer's Disease and the Mechanisms of Vanadium Compounds in Curing AD.Current issues in molecular biology · 2023Review
- Article
- Alzheimer's Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound.International journal of molecular sciences · 2021Review
- Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages ofMolecules (Basel, Switzerland) · 2021Article
- Anticancer effect of sodium metavanadate on murine breast cancer both in vitro and in vivo.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells.Molecules (Basel, Switzerland) · 2020Review
- Evaluation of the genotoxicity, cytotoxicity and antimalarial effect of sodium metavanadateToxicology reports · 2020Article
- Biospeciation of Potential Vanadium Drugs of Acetylacetonate in the Presence of Proteins.Frontiers in chemistry · 2020Article
- Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus.Biological trace element research · 2019Review
- New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines.International journal of molecular sciences · 2019Article
- Real-time Analysis of Impedance Alterations by the Effects of Vanadium Pentoxide on Several Carcinoma Cell Lines.Turkish journal of pharmaceutical sciences · 2018Article
- Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Vanadium Compounds as PTP Inhibitors.Molecules (Basel, Switzerland) · 2017Review
- Article
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3 authors at 1 institution in 1 country.
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Abstract
In this study, the antiproliferative effect of bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate and the underlying mechanisms were investigated in human pancreatic cancer cell line AsPC-1. The results showed that both exhibited an antiproliferative effect through inducing G2/M cell cycle arrest and can also cause elevation of reactive oxygen species (ROS) levels in cells. Moreover, the two vanadium compounds induced the activation of both PI3K/AKT and MAPK/ERK signaling pathways dose- and time-dependently, which could be counteracted with the antioxidant N-acetylcysteine. In the presence of MEK-1 inhibitor, the degradation of Cdc25C, inactivation of Cdc2 and accumulation of p21 were relieved. However, the treatment of AKT inhibitor did not cause any significant effect. Therefore, it demonstrated that the ROS-induced sustained MAPK/ERK activation rather than AKT contributed to vanadium compounds-induced G2/M cell cycle arrest. The current results also exhibited that the two vanadium compounds did not induce a sustained increase of ROS generation, but the level of ROS reached a plateau instead. The results revealed that an intracellular feedback loop may be against the elevated ROS level induced by vanadate or VO(acac)
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