Evidence map›Paper›PMID 27614087›Full record

ArticleJournal of neuroscience research2017

Preferential conduction block of myelinated axons by nitric oxide.

Peter Shrager, Margaret Youngman

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroscience research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Deletion of murineScience translational medicine · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter ShragerDepartment of Neuroscience, University of Rochester Medical Center, Rochester, New York.
Margaret YoungmanDepartment of Neuroscience, University of Rochester Medical Center, Rochester, New York.
University of Rochester Medical Center · US

Funding

Neuronal regulation of myelinationR01NS081281 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIGER, ROMAN JENO · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS081281
6 · The paper itself

Abstract

Conduction block by nitric oxide (NO) was examined in myelinated and unmyelinated axons from both the central nervous system and peripheral nervous system. In rat vagus nerves, mouse optic nerves at P12-P23, adult and developing mouse sciatic nerves, and mouse spinal cords, myelinated fibers were preferentially blocked reversibly by concentrations of NO similar to those encountered in inflammatory lesions. The possibility that these differences between myelinated and unmyelinated axons are due to the normal developmental substitution of Na

Indexed as

AnimalsAutonomic Nerve BlockMiceMice, KnockoutMice, TransgenicNerve Fibers, MyelinatedNeural ConductionNitric OxideOrgan Culture TechniquesRatsRats, Inbred LewVagus NerveNitric Oxideinflammationion channelsshiverer (RRID:IMSR_JAX:001428)unmyelinated

Identifiers

PMID27614087
PMCPMC5346061
OpenAlexW2518977694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.