ArticlePhysiology & behavior2016
Memory-dependent effects on palatability in mice.
Article in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Are mice a bad model for successive negative contrast?Learning & behavior · 2026Review
- The Development of Risperidone-Loaded Microfibers via Centrifugal Spinning to Enhance the Palatability of a Potential Drug for Autistic Children.Pharmaceutics · 2025Article
- Self-driven solutions and resilience adapted by people with drug-resistant tuberculosis and their caregivers in Bengaluru and Hyderabad, India: a qualitative study.The Lancet regional health. Southeast Asia · 2024Article
- Prior experience with flavored alcohol increases preference for flavored alcohol but flavor does not influence binge-like drinking behavior in mice.Physiology & behavior · 2023Article
- Article
- Lipopolysaccharide does not alter behavioral response to successive negative contrast in mice.Psychopharmacology · 2021Article
- The GluA1 AMPAR subunit is necessary for hedonic responding but not hedonic value in female mice.Physiology & behavior · 2021Article
- Adaptations to Oral and Pharyngeal Swallowing Function Induced by Injury to the Mylohyoid Muscle.Dysphagia · 2020Article
- Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Review
- Examining the influence of CS duration and US density on cue-potentiated feeding through analyses of licking microstructure.Learning and motivation · 2018Article
- A biphasic reduction in a measure of palatability following sucrose consumption in mice.Physiology & behavior · 2018Article
- GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.Scientific reports · 2017Article
- Within-session decrement of the emission of licking bursts following reward devaluation in rats licking for sucrose.PloS one · 2017Article
- Contexts control negative contrast and restrict the expression of flavor preference conditioning.Journal of experimental psychology. Animal learning and cognition · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
While palatability depends on the properties of particular foods, it is also determined by prior experience, suggesting that memory affects the hedonic value of a substance. Here, we report two procedures that affect palatability in mice: negative contrast and flavour habituation. A microstructure analysis of licking behaviour was employed, with the lick cluster size (the number of licks made in quick succession before a pause) used as a measure of palatability. It was first confirmed that lick cluster size increased monotonically as a function of sucrose concentration, whereas consumption followed an inverted U-shaped function. In a successive negative contrast procedure it was found that when shifted from a high sucrose concentration (32%) to a low sucrose concentration (4%), mice made smaller lick clusters than a group that only received the low concentration. Mice exposed to flavours (cherry or grape Kool Aid) mixed with sucrose (16%) made larger lick clusters for familiar flavours compared to novel flavours. This habituation effect was evident after short (5min) and long (24h) test intervals. Both successive negative contrast and flavour habituation failed to affect levels of consumption. Collectively, the results show that prior experience can have effects on lick cluster size that are equivalent to increasing or decreasing the sweetness of a solution. Thus, palatability is not a fixed property of a substance but is dependent on expectation or familiarity that occurs as a result of memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.