Observational studyNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2016
Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients?
Observational study in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Strategies and successes of smoking cessation methods in head and neck cancer patients: a systematic review.Cancer metastasis reviews · 2026Pooled it
- Post-diagnosis smoking cessation and survival of patients with head and neck cancer: a systematic review and meta-analysis.British journal of cancer · 2022Pooled it
- Quality of smoking cessation advice in guidelines of tobacco-related diseases: An updated systematic review.Clinical medicine (London, England) · 2020Pooled it
- Pilot randomized controlled trial of a comprehensive smoking cessation intervention for patients with upper aerodigestive cancer undergoing radiotherapy.Head & neck · 2018Trial
- Postdiagnosis Smoking Cessation and Survival Outcomes of Head and Neck Cancer Patients.Head & neck · 2025Article
- Tobacco Assessment in Actively Accruing National Cancer Institute Clinical Trials Network Trials.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Cigarette Smoking and Symptom Burden: Baseline Results From Nine ECOG-ACRIN Cancer Clinical Trials.Journal of pain and symptom management · 2025Article
- The role of nurses in smoking cessation interventions for patients: a scoping review.BMC nursing · 2024Article
- Tobacco Cessation Following Laryngeal Cancer Diagnosis Predicts Response to Treatment and Laryngectomy-Free Survival.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells.International journal of molecular sciences · 2024Article
- Tobacco use and cancer-related symptom burden: Analysis of the US Population Assessment of Tobacco and Health Study.Cancer · 2023Article
- Brief intervention to enhance cessation of smokeless tobacco use in newly diagnosed patients with head and neck cancers: A randomized controlled trial in patient-relative dyads.Indian journal of psychiatry · 2023Article
- Tobacco cessation after head and neck cancer diagnosis is an independent predictor of treatment response and long-term survival.Oral oncology · 2022Article
- A Daily Assessment Study of Smoking Cessation After a Head and Neck Cancer Diagnosis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Has the National Fall in Smoking Rates in Ireland Been Replicated in Cancer Patients? A 5-Year Report.International journal of environmental research and public health · 2022Article
- How Self-Efficacy toward, Perceived Importance of, and Beliefs about Smoking Cessation Support Impact-Related Behaviors in Japanese Nursing Professionals.International journal of environmental research and public health · 2022Article
- The characteristics of patients who quit smoking in the year following a cancer diagnosis.Journal of cancer survivorship : research and practice · 2022Article
- Effectiveness of a smoking cessation educational program for Japanese nurses on subsequent changes of behavior in delivering smoking cessation counseling.Tobacco induced diseases · 2022Article
- Mixed-methods economic evaluation of the implementation of tobacco treatment programs in National Cancer Institute-designated cancer centers.Implementation science communications · 2021Article
- Identifying Best Implementation Practices for Smoking Cessation in Complex Cancer Settings.Current oncology (Toronto, Ont.) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
introductionTo determine if smoking after a cancer diagnosis makes a difference in mortality among newly diagnosed head and neck cancer patients.
methodsLongitudinal data were collected from newly diagnosed head and neck cancer patients with a median follow-up time of 1627 days (N = 590). Mortality was censored at 8 years or September 1, 2011, whichever came first. Based on smoking status, all patients were categorized into four groups: continuing smokers, quitters, former smokers, or never-smokers. A broad range of covariates were included in the analyses. Kaplan-Meier curves, bivariate and multivariate Cox proportional hazards models were constructed.
resultsEight-year overall mortality and cancer-specific mortality were 40.5% (239/590) and 25.4% (150/590), respectively. Smoking status after a cancer diagnosis predicted overall mortality and cancer-specific mortality. Compared to never-smokers, continuing smokers had the highest hazard ratio (HR) of dying from all causes (HR = 2.71, 95% confidence interval [CI] = 1.48-4.98). Those who smoked at diagnosis, but quit and did not relapse-quitters-had an improved hazard ratio of dying (HR = 2.38, 95% CI = 1.29-4.36) and former smokers at diagnosis with no relapse after diagnosis-former smokers-had the lowest hazard ratio of dying from all causes (HR = 1.68, 95% CI = 1.12-2.56). Similarly, quitters had a slightly higher hazard ratio of dying from cancer-specific reasons (HR = 2.38, 95% CI = 1.13-5.01) than never-smokers, which was similar to current smokers (HR = 2.07, 95% CI = 0.96-4.47), followed by former smokers (HR = 1.70, 95% CI = 1.00-2.89).
conclusionsCompared to never-smokers, continuing smokers have the highest HR of overall mortality followed by quitters and former smokers, which indicates that smoking cessation, even after a cancer diagnosis, may improve overall mortality among newly diagnosed head and neck cancer patients. Health care providers should consider incorporating smoking cessation interventions into standard cancer treatment to improve survival among this population. IMPLICATIONS: Using prospective observational longitudinal data from 590 head and neck cancer patients, this study showed that continuing smokers have the highest overall mortality relative to never-smokers, which indicates that smoking cessation, even after a cancer diagnosis, may have beneficial effects on long-term overall mortality. Health care providers should consider incorporating smoking cessation interventions into standard cancer treatment to improve survival among this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.