Evidence map›Paper›PMID 27613895›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2017

Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.

Whitney E Melroy-Greif, Matthew A Simonson, Robin P Corley, Sharon M Lutz, John E Hokanson, Marissa A Ehringer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Whitney E Melroy-GreifDepartment of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA.
Matthew A SimonsonMassachusetts Institute of Technology, Cambridge, MA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO.
Sharon M LutzDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Marissa A EhringerInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · USMassachusetts Institute of Technology · USScripps Research Institute · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Alcohol Research in the Science/Practitioner ModelT32AA013525 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY, ANDREA SPADONI TOWNSEND · 2002 to 2026
$8.4M
GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCER01DA012845 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 2000 to 2012
$7.1M
Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Translational studies of nicotinic receptor genes: alcohol and nicotine behaviorsR01AA017889 · NIAAA · UNIVERSITY OF COLORADO · PI EHRINGER, MARISSA A · 2009 to 2013
$2.6M
Common Genetic Pathways Underlying CVD and COPDK01HL125858 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LUTZ, SHARON MARIE · 2015 to 2019
$721k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS K01 HL125858NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIAAA NIH HHS R01 AA017889NIAAA NIH HHS T32 AA013525NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA012845NIDA NIH HHS T32 DA017637
6 · The paper itself

Abstract

introductionCigarette smoking is a physiologically harmful habit. Nicotinic acetylcholine receptors (nAChRs) are bound by nicotine and upregulated in response to chronic exposure to nicotine. It is known that upregulation of these receptors is not due to a change in mRNA of these genes, however, more precise details on the process are still uncertain, with several plausible hypotheses describing how nAChRs are upregulated. We have manually curated a set of genes believed to play a role in nicotine-induced nAChR upregulation. Here, we test the hypothesis that these genes are associated with and contribute risk for nicotine dependence (ND) and the number of cigarettes smoked per day (CPD).

methodsStudies with genotypic data on European and African Americans (EAs and AAs, respectively) were collected and a gene-based test was run to test for an association between each gene and ND and CPD.

resultsAlthough several novel genes were associated with CPD and ND at P < 0.05 in EAs and AAs, these associations did not survive correction for multiple testing. Previous associations between CHRNA3, CHRNA5, CHRNB4 and CPD in EAs were replicated.

conclusionsOur hypothesis-driven approach avoided many of the limitations inherent in pathway analyses and provided nominal evidence for association between cholinergic-related genes and nicotine behaviors. IMPLICATIONS: We evaluated the evidence for association between a manually curated set of genes and nicotine behaviors in European and African Americans. Although no genes were associated after multiple testing correction, this study has several strengths: by manually curating a set of genes we circumvented the limitations inherent in many pathway analyses and tested several genes that had not yet been examined in a human genetic study; gene-based tests are a useful way to test for association with a set of genes; and these genes were collected based on literature review and conversations with experts, highlighting the importance of scientific collaboration.

Indexed as

Black or African AmericanReceptors, NicotinicWhite PeopleHumansNicotineSmokingNicotineReceptors, Nicotinic

Identifiers

PMID27613895
PMCPMC5868095
OpenAlexW2509384557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.