Evidence map›Paper›PMID 27613870›Full record

ArticleThe Journal of biological chemistry2016

Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.

Mohammad Mahfuzul Haque, Sougata Sinha Ray, Dennis J Stuehr

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Redox-Regulation of α-Globin in Vascular Physiology.Antioxidants (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  9. Article
  10. Generation and characterization of functional phosphoserine-incorporated neuronal nitric oxide synthase holoenzyme.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  11. Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad Mahfuzul HaqueFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 haquem@ccf.org.
Sougata Sinha RayFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Dennis J StuehrFrom the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 stuehrd@ccf.org.

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
CONTROL MECHANISMS OF THE NITRIC OXIDE SYNTHASESR01GM051491 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI STUEHR, DENNIS J · 1994 to 2016
$5.1M
NHLBI NIH HHS P01 HL076491NIGMS NIH HHS R01 GM051491
6 · The paper itself

Abstract

The activity of endothelial NO synthase (eNOS) is triggered by calmodulin (CaM) binding and is often further regulated by phosphorylation at several positions in the enzyme. Phosphorylation at Ser

Indexed as

Amino Acid MotifsAmino Acid SubstitutionAnimalsCattleCytochromes cFlavinsKineticsNitric OxideNitric Oxide Synthase Type IIIPhosphorylationProtein ConformationCytochromes cFlavinsNitric OxideNitric Oxide Synthase Type IIIcatalysiselectron transfereNOSfast reaction kineticsflavoproteinheme reductionkinetic modelnitric oxide synthasepre-steady-state kineticssimulation

Identifiers

PMID27613870
PMCPMC5087725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.