Evidence map›Paper›PMID 27613807›Full record

SynthesisAnnals of the rheumatic diseases2017

International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials.

Ana-Maria Orbai, Maarten de Wit, Philip Mease, Judy A Shea, Laure Gossec, Ying Ying Leung, William Tillett, Musaab Elmamoun, Kristina Callis Duffin, Willemina Campbell and 17 more

Registry-linked trialOpen access · hybridAbstract readConsensus StatementSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03620188 (Are we Meeting Patient Treatment Goals With Guideline-based Therapy for Psoriatic Arthritis), which is not on this map. Cited by 114 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 7 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03620188 completednot on this mapstarted 2018, after this paper: background citation

Are we Meeting Patient Treatment Goals With Guideline-based Therapy for Psoriatic Arthritis

TypeobservationalSponsorJohns Hopkins UniversityRan2018 to 2022Enrolled250ConditionsPsoriatic ArthritisArmsStandard of care
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 7 syntheses or guidelines pooled it, 269 citations in OpenAlex.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 16 institutions in 9 countries.

Ana-Maria OrbaiDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maarten de WitDepartment of Medical Humanities, Patient Research Partner, VU University Medical Centre, Amsterdam, The Netherlands.
Philip MeaseSwedish Medical Center and University of Washington, Seattle, Washington, USA.
Judy A SheaUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Laure GossecSorbonne Universités, UPMC Univ Paris 06, GRC-08, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.ORCID http://orcid.org/0000-0002-4528-310X
Ying Ying LeungDepartment of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0001-8492-6342
William TillettRoyal National Hospital for Rheumatic Diseases and the University of Bath, Bath, UK.
Musaab ElmamounSt. Vincent's University Hospital and the Conway Institute, University College Dublin (UCD), Dublin, Ireland.
Kristina Callis DuffinDepartment of Dermatology, University of Utah, Salt Lake City, Utah, USA.
Willemina CampbellPatient Research Partner, Toronto, Ontario, Canada.
Robin ChristensenThe Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark.
Laura CoatesLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Emma DuresDepartment of Nursing, University of the West of England, Bristol, UK.
Lihi EderWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Oliver FitzGeraldSt. Vincent's University Hospital and the Conway Institute, University College Dublin (UCD), Dublin, Ireland.
Dafna GladmanToronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Niti GoelPatient Research Partner, Advisory Services, Quintiles, Durham, North Carolina, USA.
Suzanne Dolwick GriebJohns Hopkins School of Medicine, Baltimore, Maryland, USA.
Sarah HewlettDepartment of Nursing, University of the West of England, Bristol, UK.
Pil HoejgaardThe Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark.
Umut KalyoncuDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Chris LindsayPatient Research Partner, Thousand Oaks, California, USA.
Neil McHughRoyal National Hospital for Rheumatic Diseases and the University of Bath, Bath, UK.
Bev SheaOttawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Ingrid SteinkoenigPatient Research Partner, Cleveland, Ohio, USA.
Vibeke StrandDivision of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA.
Alexis OgdiePerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Johns Hopkins University · USFrederiksberg Hospital · DKRoyal National Hospital for Rheumatic Diseases · GBUniversity College Dublin · IEUniversity of Pennsylvania · USUniversity of the West of England · GBUniversity of Toronto · CAAmsterdam UMC Location Vrije Universiteit Amsterdam · NLDuke University · USSingapore General Hospital · SGSorbonne Université · FRStanford University · USUniversity of Leeds · GBUniversity of Ottawa · CAUniversity of Utah · USUniversity of Washington · US

Funding

Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, Antony Rosen · 2016 to 2026
$8.9M
Phenotype-Specific Immune Responses in the Systemic VasculitidesP30AR053503 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SOLOSKI, MARK J · 2006 to 2015
$6.4M
Identification of Early Psoriatic ArthritisK23AR063764 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI OGDIE, ALEXIS R. · 2013 to 2017
$751k
Department of Health RP-PG-1212-20007NIAMS NIH HHS K23 AR063764NIAMS NIH HHS P30 AR053503NIAMS NIH HHS P30 AR070254
6 · The paper itself

Abstract

objectiveTo identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities.

methodsWe conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners.

resultsWe identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation.

conclusionsThe updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains.

Indexed as

Attitude of Health PersonnelPatient Reported Outcome MeasuresPhysiciansAdolescentAdultAgedArthritis, PsoriaticClinical Trials as TopicFatigueFemaleFocus GroupsHealth StatusHumansInflammationInternationalityMaleOutcomes researchPsoriatic ArthritisQualitative researchSpondyloarthritis

Identifiers

PMID27613807
PMCPMC5344772
OpenAlexW2514573576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.