Evidence map›Paper›PMID 27613721›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus.

A A Khan, D A Hanley, R Rizzoli, J Bollerslev, J E M Young, L Rejnmark, R Thakker, P D'Amour, T Paul, S Van Uum and 22 more

Open access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
232citing papers in PubMed, 9 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

232 citing papers in PubMed, 9 syntheses or guidelines pooled it, 523 citations in OpenAlex.

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  6. Parathyroidectomy for adults with primary hyperparathyroidism.The Cochrane database of systematic reviews · 2023
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  7. Assessment and Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
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172 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 12 countries.

A A KhanMcMaster University, Hamilton, Canada. Aliya@mcmaster.ca.
D A HanleyUniversity of Calgary, Calgary, Canada.
R RizzoliDivision of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
J BollerslevUniversity of Oslo, Oslo, Norway.
J E M YoungMcMaster University, Hamilton, Canada.
L RejnmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
R ThakkerUniversity of Oxford, Oxford, UK.
P D'AmourCHUM, Montreal, Canada.
T PaulWestern University, London, ON, Canada.
S Van UumWestern University, London, ON, Canada.
M Zakaria ShrayyefDivision of Endocrinology, University of Toronto, Mississauga, ON, Canada.
D GoltzmanMcGill University, Montreal, Canada.
S KaiserDalhousie University, Halifax, Canada.
N E CusanoColumbia University College of Physicians and Surgeons, New York, NY, USA.
R BouillonKU, Leuven, Belgium.
L MosekildeUniversity of Aarhus, Aarhus, Denmark.
A W KungUniversity of Hong Kong, Hong Kong, China.
S D RaoHenry Ford Hospital, Detroit, MI, USA.
S K BhadadaPostgraduate Institute of Medical Education and Research, Chandigarth, India.
B L ClarkeMayo Clinic, Rochester, MN, USA.
J LiuRui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Q DuhUniversity of California, San Francisco, CA, USA.
E Michael LewieckiNew Mexico Clinical Research and Osteoporosis Center, University of New Mexico School of Medicine, Albuquerque, NM, USA.
F BandeiraDivision of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalhaes Hospital, Brazilian Ministry of Health, University of Pernambuco Medical School, Recife, Brazil.
R EastellDepartment of Human Metabolism, University of Sheffield, Sheffield, UK.
C MarcocciDepartment for Clinical and Experimental Medicine, University of Pisa, Endocrine Unit 2, University Hospital of Pisa, Pisa, Italy.
S J SilverbergDivision of Endocrinology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
R UdelsmanDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA.
K Shawn DavisonUniversity of Victoria, Victoria, BC, Canada.
J T PottsMassachusetts General Hospital, Harvard University, Boston, MA, USA.
M L BrandiUniversity of Florence, Florence, Italy.
J P BilezikianDivision of Endocrinology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Columbia University · USMcMaster University · CAWestern University · CAAarhus University · DKAarhus University Hospital · DKCentre Hospitalier de l’Université de Montréal · CADalhousie University · CAHenry Ford Hospital · USKU Leuven · BEMassachusetts General Hospital · USMayo Clinic in Arizona · USMcGill University · CAPost Graduate Institute of Medical Education and Research · INShanghai Jiao Tong University · CNUniversidade de Pernambuco · BRUniversity Hospital of Geneva · CHUniversity of Calgary · CAUniversity of California, San Francisco · USUniversity of Florence · ITUniversity of Hong Kong · HK

Funding

PRIMARY HYPERPARATHYROIDISMR01DK032333 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BILEZIKIAN, JOHN P · 1986 to 2018
$9.6M
Non-Classical Manifestations of Primary HyperparathyroidismK24DK074457 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2006 to 2016
$1.7M
NIDDK NIH HHS K24 DK074457NIDDK NIH HHS R01 DK032333
6 · The paper itself

Abstract

The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.

Indexed as

HumansHypercalcemiaHyperparathyroidism, PrimaryIncidenceMagnetic Resonance ImagingNephrolithiasisParathyroidectomyPrevalenceRadionuclide ImagingTomography, X-Ray ComputedDiagnosisManagementOsteoporosisPrimary hyperparathyroidismSurgeryTreatment

Identifiers

PMID27613721
PMCPMC5206263
OpenAlexW2515002635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.