Evidence map›Paper›PMID 27613645›Full record

SynthesisAIDS and behavior2017

The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis.

Haochu Li, Gifty Marley, Wei Ma, Chongyi Wei, Mellanye Lackey, Qingyan Ma, Françoise Renaud, Marco Vitoria, Rachel Beanland, Meg Doherty and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  11. Factors influencing treatment adherence in hypertension and HIV management in South Africa: A comparative literature review.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haochu LiSchool of Public Health, Shandong University, Jinan, China. hcli@alumni.cuhk.net.
Gifty MarleySchool of Public Health, Shandong University, Jinan, China.
Wei MaSchool of Public Health, Shandong University, Jinan, China.
Chongyi WeiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Mellanye LackeyUNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Qingyan MaUNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Françoise RenaudHIV Department, World Health Organization, Geneva, Switzerland.
Marco VitoriaHIV Department, World Health Organization, Geneva, Switzerland.
Rachel BeanlandHIV Department, World Health Organization, Geneva, Switzerland.
Meg DohertyHIV Department, World Health Organization, Geneva, Switzerland.
Joseph D TuckerUNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. jdtucker@med.unc.edu.

Funding

Spurring Innovation in HIV Testing and Linkage: A Crowdsourcing Approach -Diversity SupplementR01AI114310 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TUCKER, JOSEPH DAVID, WEI, CHONGYI · 2014 to 2018
$3.3M
UNC-South China STD Research Training CenterD43TW009532 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON SCOTT, TUCKER, JOSEPH DAVID · 2013 to 2017
$1.3M
FIC NIH HHS D43 TW009532NIAID NIH HHS R01 AI114310World Health Organization 001
6 · The paper itself

Abstract

Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.

Indexed as

Medication AdherenceAdaptation, PsychologicalAlkynesAnti-HIV AgentsBenzoxazinesCounselingCyclopropanesDrug-Related Side Effects and Adverse ReactionsHIV InfectionsHumansQualitative ResearchAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesefavirenzAdherenceAdverse drug reactionAntiretroviralHIVQualitative meta-synthesis

Identifiers

PMID27613645
PMCPMC5290204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.