Trial reportJournal of feline medicine and surgery2017
Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study.
Trial report in Journal of feline medicine and surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- The Effect of Capromorelin and Extended-Release Buprenorphine on Body Weight in Guinea Pigs (Cavia porcellus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Owner's Perspective About the Use of Mirtazapine Transdermal Ointment in Cats-A Survey-Based Study.Animals : an open access journal from MDPI · 2025Article
- Evaluation of the Short-Term Effects of Mirtazapine on Appetite Stimulants in Dogs: A Retrospective Study and a Placebo-Controlled Trial.Animals : an open access journal from MDPI · 2025Article
- Preliminary Pharmacokinetics and Appetite Stimulant Efficacy of Oral Mirtazapine in Guinea Pigs (Animals : an open access journal from MDPI · 2025Article
- Comparison of Effects of Capromorelin and Mirtazapine on Appetite in New Zealand White Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- 2022 ISFM Consensus Guidelines on Management of the Inappetent Hospitalised Cat.Journal of feline medicine and surgery · 2022Article
- Drug-Dosing Adjustment in Dogs and Cats with Chronic Kidney Disease.Animals : an open access journal from MDPI · 2022Review
- Appetite Stimulant and Anti-Emetic Effect of Mirtazapine Transdermal Ointment in Cats Affected by Lymphoma Following Chemotherapy Administration: A Multi-Centre Retrospective Study.Animals : an open access journal from MDPI · 2022Article
- A pilot study of transdermal gabapentin in cats.Journal of veterinary internal medicine · 2021Article
- Assessment of compounded transdermal mirtazapine as an appetite stimulant in cats with chronic kidney disease.Journal of feline medicine and surgery · 2020Article
- Serum theophylline after multiple dosing with transdermal gels in cats.Journal of feline medicine and surgery · 2019Article
- A double-blind, placebo-controlled, randomized study to evaluate the weight gain drug, mirtazapine transdermal ointment, in cats with unintended weight loss.Journal of veterinary pharmacology and therapeutics · 2019Article
- Serum levetiracetam concentrations after transdermal levetiracetam administration, 3 times daily, to healthy cats.Journal of veterinary internal medicine · 2019Article
- The pharmacokinetics of gabapentin in cats.Journal of veterinary internal medicine · 2018Article
- Hepatic lipidosis: Clinical review drawn from collective effort.Journal of feline medicine and surgery · 2018Review
- Assessment of absorption of transdermal ondansetron in normal research cats.Journal of feline medicine and surgery · 2017Article
- Evaluation of the efficacy of transdermal administration of maropitant in managing vomiting in cats.Open veterinary journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Objectives The objective of this study was to measure drug exposure and clinical effects after administration of transdermal mirtazapine (TMZ) in healthy cats. Methods Phase I: seven healthy research cats received (1) 3.75 mg and 7.5 mg TMZ once aurally with 48 h serum sampling (serum samples were obtained via the jugular catheter at 0, 0.5, 1, 2, 5, 9, 12, 24, 36 and 48 h); (2) 7.5 mg TMZ and placebo daily aurally for 6 days then 48 h serum sampling; (3) 1.88 mg mirtazapine orally once with serum sampling at 1, 4 and 8 h. Phase II: 20 client-owned cats were enrolled in a randomized, double-blind, placebo-controlled, three-way crossover clinical effect study. Treatments consisted of 6 days of aural 7.5 mg TMZ or placebo gel at home, and 1.88 mg mirtazapine orally once in the clinic. Owners documented appetite, rate of food ingestion, begging activity and vocalization daily at home. On day 6, food consumed, activity and vocalization were documented in hospital, and trough and peak serum mirtazapine levels were obtained. Serum mirtazapine and gel concentrations were measured using liquid chromatography/tandem mass spectrometry. Results Phase I: administration of TMZ achieved measureable serum mirtazapine concentrations. Area under the curve
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.