Evidence map›Paper›PMID 27613421›Full record

ArticleNucleic acids research2016

Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference.

Ryan Ard, Robin C Allshire

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  5. Review
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  7. Conserved protein Pir2Nature communications · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ryan ArdWellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK.ORCID 0000-0002-9070-9747
Robin C AllshireWellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK robin.allshire@ed.ac.uk.
Wellcome Centre for Cell Biology · GB

Funding

Wellcome Trust 092076/Z/10/ZWellcome Trust 095021/Z/10/Z
6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) transcription into a downstream promoter frequently results in transcriptional interference. However, the mechanism of this repression is not fully understood. We recently showed that drug tolerance in fission yeast Schizosaccharomyces pombe is controlled by lncRNA transcription upstream of the tgp1

Indexed as

Gene Expression Regulation, FungalTranscription, GeneticAcid PhosphataseChromatinGenes, FungalGene SilencingHistone-Lysine N-MethyltransferaseHistonesMethylationPromoter Regions, GeneticProtein Processing, Post-TranslationalSchizosaccharomycesSchizosaccharomyces pombe ProteinsAcid Phosphataseacid phosphatase Pho1, S pombeChromatinHistone-Lysine N-MethyltransferaseHistonesSchizosaccharomyces pombe ProteinsSet2 protein, S pombe

Identifiers

PMID27613421
PMCPMC5159543
OpenAlexW2513525435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.