Evidence map›Paper›PMID 27613186›Full record

ArticleJournal of cancer research and clinical oncology2016

Detection of human papillomavirus-16 DNA in archived clinical samples of breast and lung cancer patients from North Pakistan.

Naureen Ehsan Ilahi, Sobia Anwar, Mamoona Noreen, Shoaib Naiyar Hashmi, Sheeba Murad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  8. HPV-Associated Breast Cancer: Myth or Fact?Pathogens (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Naureen Ehsan IlahiAtta-ur-Rahman School of Applied Biosciences, National University of Science's and Technology, H-12, Islamabad, 44000, Pakistan.
Sobia AnwarAtta-ur-Rahman School of Applied Biosciences, National University of Science's and Technology, H-12, Islamabad, 44000, Pakistan.
Mamoona NoreenAtta-ur-Rahman School of Applied Biosciences, National University of Science's and Technology, H-12, Islamabad, 44000, Pakistan.
Shoaib Naiyar HashmiArmed Forces Institute of Pathology, Rawalpindi, Pakistan.
Sheeba MuradAtta-ur-Rahman School of Applied Biosciences, National University of Science's and Technology, H-12, Islamabad, 44000, Pakistan. s.mall@asab.nust.edu.pk.
National University of Sciences and Technology · PKArmed Forces Institute of Pathology · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOver the past few decades, human papillomavirus (HPV) has been recorded as a key player in the development of various genital cancers, most notably cervical cancer. It has also been associated with some non-genital cancers. A subset of oropharyngeal cancers are known to be caused by HPV. Its aetiological involvement has been suggested for breast and lung cancer as well. However, reports regarding the HPV DNA detection vary widely from different parts of the world. Due to scarcity of local data in this regard, the current study aimed at retrospective detection of HPV presence in the archival samples of breast and lung cancer patients from north part of the country.

methodsA total of 55 formalin-fixed paraffin-embedded tissue sections of invasive ductal carcinoma of breast (n = 46) and lung (n = 9) were collected for this study. Genotyping for HPV16 and 18 was carried out through PCR.

resultsHPV16 DNA was found in both breast and lung carcinoma samples with the prevalence rate of 17 and 11 %, respectively. An interesting association was found between ER/PR (Oestrogen/Progesterone receptor) and HER2/Neu (Human epidermal growth factor receptor-2) positivity with HPV occurrence in breast tumours.

conclusionCurrent study shows the presence of HPV16 DNA in archived clinical biopsy sections from breast and lung cancers (17, 11 %), respectively. A positive correlation of HPV16 presence was found with ER/PR and HER2-positive breast cancers. These initial findings warrant further investigation in order to determine HPV prevalence and aetiological role in local cancers, especially in ER/PR/HER2-positive breast cancers on a larger scale.

Indexed as

AdultAgedBreast NeoplasmsDNA, ViralFemaleHuman papillomavirus 16HumansLung NeoplasmsMiddle AgedPakistanPapillomavirus InfectionsPrevalenceRegistriesRetrospective StudiesDNA, ViralBreast cancerHuman papillomavirusLung cancer

Identifiers

PMID27613186
PMCPMC11819334
OpenAlexW2509507929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.