Evidence map›Paper›PMID 27613061›Full record

ArticleEuropean urology2017

Partial Prostatectomy for Anterior Cancer: Short-term Oncologic and Functional Outcomes.

Arnauld Villers, Philippe Puech, Vincent Flamand, Georges-Pascal Haber, Mihir M Desai, Sebastien Crouzet, Xavier Leroy, Sameer Chopra, Laurent Lemaitre, Adil Ouzzane and 1 more

Open access · greenAbstract read
In one paragraph

Article in European urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  13. Median lobe vs. complete gland holmium laser enucleation of the prostate: A propensity score matching.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
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  20. Surveillance after prostate focal therapy.World journal of urology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Arnauld VillersDepartment of Urology, CHU Lille, Université de Lille, Lille, France; Inserm, U1189 - ONCO-THAI, CHRU Lille, Université de Lille, Lille, France. Electronic address: arnauld-villers@univ-lille2.fr.
Philippe PuechInserm, U1189 - ONCO-THAI, CHRU Lille, Université de Lille, Lille, France; Department of Radiology, CHU Lille, Université de Lille, Lille, France.
Vincent FlamandDepartment of Urology, CHU Lille, Université de Lille, Lille, France.
Georges-Pascal HaberGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Mihir M DesaiUSC Institute of Urology, Catherine and Joseph Aresty Department of Urology, University of Southern California, Los Angeles, CA, USA.
Sebastien CrouzetUrology and Transplantation Department, Edouard Herriot Hospital, Université de Lyon, Lyon, France.
Xavier LeroyDepartment of Pathology, CHU Lille, Université de Lille, Lille, France.
Sameer ChopraUSC Institute of Urology, Catherine and Joseph Aresty Department of Urology, University of Southern California, Los Angeles, CA, USA.
Laurent LemaitreInserm, U1189 - ONCO-THAI, CHRU Lille, Université de Lille, Lille, France; Department of Radiology, CHU Lille, Université de Lille, Lille, France.
Adil OuzzaneDepartment of Urology, CHU Lille, Université de Lille, Lille, France; Inserm, U1189 - ONCO-THAI, CHRU Lille, Université de Lille, Lille, France.
Inderbir S GillUSC Institute of Urology, Catherine and Joseph Aresty Department of Urology, University of Southern California, Los Angeles, CA, USA.
Inserm · FRUniversité de Lille · FRUniversity of Southern California · USCleveland Clinic · USHôpital Edouard Herriot · FR

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Saul Priceman · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

backgroundFocal ablative therapy may be a suboptimal option for anterior prostate cancers (APCs) reaching the prostate apex due to concerns for thermal injury to the external sphincter.

objectiveTo explore the technical feasibility of anterior partial prostatectomy (APP) for isolated APCs detected by magnetic resonance imaging (MRI), and to report short-term oncologic and functional outcomes. DESIGN, SETTING, AND

participantsFollowing institutional review board approval, over an 8-yr period (2008-2015) 17 consenting patients were enrolled in a prospective single-arm single-center Innovation, Development, Exploration, Assessment, Long-term (IDEAL) phase 2a study. Inclusion criteria comprised preurethral, low- to intermediate-risk APC diagnosed by MRI, and targeted biopsies. Robotic template APP was performed; posterolateral aspect of the submontanal urethra, peripheral zone, and periprostatic tissues were preserved intact. Median follow-up was 30 mo (interquartile range [IQR]: 25-70). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We noted the incidence of perioperative complications and examined reports of pathology, prostate-specific antigen (PSA), imaging, biopsies, and questionnaires. RESULTS AND LIMITATIONS: Preoperatively, median PSA was 9.8 ng/ml, Gleason score was 6-7 (3 + 4), and cancer volume was 3.7cm

conclusionsRobotic partial prostatectomy for isolated APC is feasible with good functional results. While promising, much more research is needed to verify our initial outcomes and appropriately position APP in the treatment paradigms for APC. PATIENT SUMMARY: We explored a novel approach for partial prostatic surgical ablation for prostate cancer located in the anterior part of the prostate as an alternative to other focal ablative techniques.

Indexed as

Robotic Surgical ProceduresAgedBiopsyFeasibility StudiesHumansKallikreinsMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingPostoperative ComplicationsProspective StudiesProstatectomyProstate-Specific AntigenProstatic NeoplasmsRisk AssessmentKallikreinsKLK3 protein, humanProstate-Specific AntigenFocal therapyImage-guided interventionMagnetic resonance imagingMinimally invasive surgeryProstate cancerProstatectomyRobotic surgery

Identifiers

PMID27613061
PMCPMC9084627
OpenAlexW2508701093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.