Evidence map›Paper›PMID 27612966›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016

Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.

Karamatullah Danyal, Willem de Jong, Edmund O'Brien, Robert A Bauer, David E Heppner, Andrew C Little, Milena Hristova, Aida Habibovic, Albert van der Vliet

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. NADPH Oxidases in Aortic Aneurysms.Antioxidants (Basel, Switzerland) · 2022
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Karamatullah DanyalDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Willem de JongDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Edmund O'BrienDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Robert A BauerDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
David E HeppnerDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Andrew C LittleDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Milena HristovaDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Aida HabibovicDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont.
Albert van der VlietDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont albert.van-der-vliet@uvm.edu.
University of Vermont · US

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Dual Oxidase in Airway Epithelial Repair and RemodelingR01HL085646 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2008 to 2020
$4.7M
Cigarette Smoke-derived Electrophilic Aldehydes and Airway InflammationR01ES021476 · NIEHS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2012 to 2016
$1.9M
Investigations of Redox-dependent Processes of the Airway EpitheliumF32HL129706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEPPNER, DAVID E. · 2016 to 2016
$50k
NHLBI NIH HHS F32 HL129706NHLBI NIH HHS R01 HL085646NHLBI NIH HHS T32 HL076122NIEHS NIH HHS R01 ES021476
6 · The paper itself

Abstract

Acrolein is a major thiol-reactive component of cigarette smoke (CS) that is thought to contribute to increased asthma incidence associated with smoking. Here, we explored the effects of acute acrolein exposure on innate airway responses to two common airborne allergens, house dust mite and Alternaria alternata, and observed that acrolein exposure of C57BL/6 mice (5 ppm, 4 h) dramatically inhibited innate airway responses to subsequent allergen challenge, demonstrated by attenuated release of the epithelial-derived cytokines IL-33, IL-25, and IL-1α. Acrolein and other anti-inflammatory thiol-reactive electrophiles, cinnamaldehyde, curcumin, and sulforaphane, similarly inhibited allergen-induced production of these cytokines from human or murine airway epithelial cells in vitro. Based on our previous observations indicating the importance of Ca

Indexed as

AcroleinAdministration, InhalationAllergensAnimalsBronchiCalciumCysteineDual OxidasesEnzyme ActivationEpithelial CellsErbB ReceptorsHumansHydrogen PeroxideImmunity, InnateInterleukin-33Mice, Inbred C57BLAcroleinAllergensCalciumCysteineDual OxidasesDuox1 protein, mouseErbB ReceptorsHydrogen PeroxideInterleukin-33NADPH Oxidasessrc-Family KinasesSulfhydryl Compoundsairway epitheliumasthmacigarette smokecysteine oxidationdual oxidase 1IL-33

Identifiers

PMID27612966
PMCPMC5130541
OpenAlexW2510339943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.