ArticleMaterials science & engineering. C, Materials for biological applications2016
Fabrication and characterization of carboxymethyl cellulose novel microparticles for bone tissue engineering.
Article in Materials science & engineering. C, Materials for biological applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Regulating Tissue Growth Factors for Healing With Etherified Carboxymethylcellulose Matrix.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- Article
- Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery.Bioactive materials · 2023Review
- Application of 3D-bioprinted nanocellulose and cellulose derivative-based bio-inks in bone and cartilage tissue engineering.International journal of bioprinting · 2023Article
- Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Recent Progress on Cellulose-Based Ionic Compounds for Biomaterials.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review.International journal of dentistry · 2021Review
- Biomaterials to Prevent Post-Operative Adhesion.Materials (Basel, Switzerland) · 2020Review
- Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration.Materials science & engineering. C, Materials for biological applications · 2020Review
- Investigation on the Preparation and Properties of CMC/magadiite Nacre-Like Nanocomposite Films.Polymers · 2019Article
- Chitosan microparticles based polyelectrolyte complex scaffolds for bone tissue engineering in vitro and effect of calcium phosphate.Carbohydrate polymers · 2018Article
- Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration.Materials science & engineering. C, Materials for biological applications · 2018Article
- Reduced graphene oxide-loaded nanocomposite scaffolds for enhancing angiogenesis in tissue engineering applications.Royal Society open science · 2018Article
- Nano-scale characterization of nano-hydroxyapatite incorporated chitosan particles for bone repair.Colloids and surfaces. B, Biointerfaces · 2018Article
- Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2018Article
- Injectable nanosilica-chitosan microparticles for bone regeneration applications.Journal of biomaterials applications · 2018Article
- Reconstruction of Craniomaxillofacial Bone Defects Using Tissue-Engineering Strategies with Injectable and Non-Injectable Scaffolds.Journal of functional biomaterials · 2017Review
- Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field.Materials (Basel, Switzerland) · 2017Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In this study we developed carboxymethyl cellulose (CMC) microparticles through ionic crosslinking with the aqueous ion complex of zirconium (Zr) and further complexing with chitosan (CS) and determined the physio-chemical and biological properties of these novel microparticles. In order to assess the role of Zr, microparticles were prepared in 5% and 10% (w/v) zirconium tetrachloride solution. Scanning electron microscopy (SEM) with energy dispersive X-ray spectrometer (EDS) results showed that Zr was uniformly distributed on the surface of the microparticles as a result of which uniform groovy surface was obtained. We found that Zr enhances the surface roughness of the microparticles and stability studies showed that it also increases the stability of microparticles in phosphate buffered saline. The crosslinking of anionic CMC with cationic Zr and CS was confirmed by Fourier transform infrared spectroscopy (FTIR) results. The response of murine pre-osteoblasts (OB-6) when cultured with microparticles was investigated. Live/dead cell assay showed that microparticles did not induce any cytotoxic effects as cells were attaching and proliferating on the well plate as well as along the surface of microparticles. In addition, SEM images showed that microparticles support the attachment of cells and they appeared to be directly interacting with the surface of microparticle. Within 10days of culture most of the top surface of microparticles was covered with a layer of cells indicating that they were proliferating well throughout the surface of microparticles. We observed that Zr enhances the cell attachment and proliferation as more cells were present on microparticles with 10% Zr. These promising results show the potential applications of CMC-Zr microparticles in bone tissue engineering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.