Evidence map›Paper›PMID 27612622›Full record

ArticleDNA repair2016

Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases.

E John Tokarsky, Varun V Gadkari, Walter J Zahurancik, Chanchal K Malik, Ashis K Basu, Zucai Suo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E John TokarskyDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biophysics Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: tokarsky.8@osu.edu.
Varun V GadkariDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gadkari.3@osu.edu.
Walter J ZahurancikDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: zahurancik.2@osu.edu.
Chanchal K MalikDepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USA. Electronic address: malikchanchal@gmail.com.
Ashis K BasuDepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USA. Electronic address: ashis.basu@uconn.edu.
Zucai SuoDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: suo.3@osu.edu.
The Ohio State University · USUniversity of Connecticut · US

Funding

BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENESR01ES009127 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI BASU, ASHIS K, SUO, ZUCAI · 1998 to 2014
$3.5M
Biological Effects of DNA Adducts Formed by Nitroaromatic CompoundsR56ES009127 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI BASU, ASHIS K, SUO, ZUCAI · 2009 to 2009
$393k
NIEHS NIH HHS R01 ES009127NIEHS NIH HHS R56 ES009127
6 · The paper itself

Abstract

3-Nitrobenzanthrone (3-NBA), a byproduct of diesel exhaust, is highly present in the environment and poses a significant health risk. Exposure to 3-NBA results in formation of N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG

Indexed as

DNA DamageDNA ReplicationBenz(a)AnthracenesDNADNA AdductsDNA-Directed DNA PolymeraseDNA Polymerase iotaDNA RepairGuanineHEK293 CellsHumansKineticsMutagensNuclear ProteinsNucleotidyltransferasesY-Family DNA Polymerases3-nitrobenzanthroneBenz(a)AnthracenesDNADNA AdductsDNA-Directed DNA PolymeraseDNA Polymerase iotaGuanineMutagensNuclear ProteinsNucleotidyltransferasesPOLI protein, humanPOLK protein, humanRad30 proteinREV1 protein, humanY-Family DNA Polymerases3-NitrobenzanthroneDNA repairDNA replicationHuman DNA polymerase etaTranslesion synthesis

Identifiers

PMID27612622
PMCPMC5048595
OpenAlexW2514369872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.