ArticleMedical science monitor : international medical journal of experimental and clinical research2016
Association of Chemerin and Vascular Endothelial Growth Factor (VEGF) with Diabetic Nephropathy.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Nephroprotective Effects ofCurrent issues in molecular biology · 2025Article
- Advances in 3D printing combined with tissue engineering for nerve regeneration and repair.Journal of nanobiotechnology · 2025Review
- The Expression and Molecular Mechanisms of Matrix Metalloproteinase- 9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats.Current molecular medicine · 2024Article
- Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.Cardiovascular research · 2023Article
- Urinary chemerin as a potential biomarker for inflammatory bowel disease.Frontiers in medicine · 2022Article
- Carbocistein improves airway remodeling in asthmatic mice.American journal of translational research · 2022Article
- Article
- Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword (Review).Molecular medicine reports · 2021Review
- Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.Molecular vision · 2021Article
- Based on Network Pharmacology and Molecular Docking to Explore the Underlying Mechanism of Huangqi Gegen Decoction for Treating Diabetic Nephropathy.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Elevated blood urea nitrogen is associated with recurrence of post-operative chronic subdural hematoma.BMC neurology · 2020Article
- Chemerin as a Driver of Hypertension: A Consideration.American journal of hypertension · 2020Review
- Multiplex Bead Array Assay of a Panel of Circulating Cytokines and Growth Factors in Patients with Albuminuric and Non-AlbuminuricDiabetic Kidney Disease.Journal of clinical medicine · 2020Article
- Article
- Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation.Journal of endocrinological investigation · 2019Review
- Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.Journal of cellular and molecular medicine · 2019Article
- Soluble Dipeptidyl Peptidase-4 Levels Are Associated with Decreased Renal Function in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2019Article
- Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes.International journal of endocrinology · 2019Article
- Chemerin: a multifaceted adipokine involved in metabolic disorders.The Journal of endocrinology · 2018Review
- Chemerin/chemR23 association with endothelial-mesenchymal transition in diabetic nephropathy.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Diabetic nephropathy (DN) is a common complication of diabetes, caused by diabetic microvascular lesions. The pathogenesis of DN is complicated, involving genetics, physics, chemistry, and environmental factors. Chemerin is a fat cell factor that participates in regulating inflammation. Vascular endothelial growth factor (VEGF) promotes vascular endothelial cell proliferation, differentiation, and angiogenesis. The relationship role of Chemerin and VEGF in DN is not fully understood. MATERIAL AND METHODS SD rats were randomly divided into 2 groups: the control group and the DN group. Streptozotocin was used to construct the DN model. Serum creatinine (Scr), blood urea nitrogen (BUN), and urine microalbumin (UAlb) were detected. Real-time PCR and Western blot were used to test Chemerin and VEGF mRNA and protein expression in kidney tissue. ELISA was performed to test TGF-β1, TNF-α, and INF-γ levels. The correlation of Chemerin and VEGF with renal function and inflammatory factors was analyzed. RESULTS DN group rats showed obviously increased Scr and BUN levels, and elevated TGF-β1, TNF-α, and INF-γ secretion (P<0.05). Compared with controls, Chemerin and VEGF were clearly overexpressed in the DN group (P<0.05). Chemerin and VEGF expression were positively correlated with inflammatory factors and renal function. CONCLUSIONS Chemerin and VEGF play important roles in DN by regulating inflammatory factors and renal function. They may be treated as indicators of DN.
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