Evidence map›Paper›PMID 27612487›Full record

Trial reportJournal of general internal medicine2017

Patient and Partner Feedback Reports to Improve Statin Medication Adherence: A Randomized Control Trial.

Ashok Reddy, Tiffany L Huseman, Anne Canamucio, Steven C Marcus, David A Asch, Kevin Volpp, Judith A Long

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02480530 (Evaluating Individual and Patient-Selected Family/Friend/or Reciprocal Peer Notifications to Improve Statin Medication Adherence Among Patients With Coronary Artery Disease), which is not on this map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02480530 nacompletednot on this map

Evaluating Individual and Patient-Selected Family/Friend/or Reciprocal Peer Notifications to Improve Statin Medication Adherence Among Patients With Coronary Artery Disease

TypeinterventionalSponsorCorporal Michael J. Crescenz VA Medical CenterRan2014 to 2015Enrolled126ConditionsCoronary Artery Disease, AdherenceArmsIndividual Feedback, Feedback Friend
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  10. Partners and Alerts in Medication Adherence: A Randomized Clinical Trial.Journal of general internal medicine · 2018 · on this map
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ashok ReddyDivision of General Internal Medicine, University of Washington School of Medicine, Seattle, WA, USA. reddya@uw.edu.
Tiffany L HusemanVISN 4 Center for Evaluation of PACT, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Anne CanamucioVISN 4 Center for Evaluation of PACT, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Steven C MarcusSchool of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA.
David A AschVISN 4 Center for Evaluation of PACT, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Kevin VolppVISN 4 Center for Evaluation of PACT, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Judith A LongVISN 4 Center for Evaluation of PACT, Philadelphia VA Medical Center, Philadelphia, PA, USA.
Philadelphia VA Medical Center · USUniversity of Pennsylvania · USUniversity of Washington · USVA Healthcare-VISN 4 · US

Funding

The Penn Roybal Center on Behavioral Economics and Health: Solving for Scale and Impact with Design Thinking, Digital Platforms, and Dynamic AdaptationP30AG034546 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Alison Meredith Buttenheim, KEVIN G VOLPP · 2009 to 2026
$10.6M
NIA NIH HHS P30 AG034546
6 · The paper itself

Abstract

backgroundSimple nudges such as reminders and feedback reports to either a patient or a partner may facilitate improved medication adherence.

objectiveTo test the impact of a pill bottle used to monitor adherence, deliver a daily alarm, and generate weekly medication adherence feedback reports on statin adherence.

designThree-month, three-arm randomized clinical trial (ClinicalTrials.gov identifier: NCT02480530).

participantsOne hundred and twenty-six veterans with known coronary artery disease and poor adherence (medication possession ratio <80 %).

interventionPatients were randomized to one of three groups: (1) a control group (n = 36) that received a pill-monitoring device with no alarms or feedback; (2) an individual feedback group (n = 36) that received a daily alarm and a weekly medication adherence feedback report; and (3) a partner feedback group (n = 54) that received an alarm and a weekly feedback report that was shared with a friend, family member, or a peer. The intervention continued for 3 months, and participants were followed for an additional 3 months after the intervention period. MAIN MEASURES: Adherence as measured by pill bottle. Secondary outcomes included change in LDL (mg/dl), patient activation, and social support. KEY

resultsDuring the 3-month intervention period, medication adherence was higher in both feedback arms than in the control arm (individual feedback group 89 %, partner feedback group 86 %, control group 67 %; p < 0.001 and = 0.001). At 6 months, there was no difference in medication adherence between either of the feedback groups and the control (individual feedback 60 %, partner feedback 52 %, control group 54 %; p = 0.75 and 0.97).

conclusionsDaily alarms combined with individual or partner feedback reports improved statin medication adherence. While neither an individual feedback nor partner feedback strategy created a sustainable medication adherence habit, the intervention itself is relatively easy to implement and low cost.

Indexed as

Drug MonitoringFeedbackReminder SystemsAgedCholesterol, LDLCoronary Artery DiseaseDrug PackagingFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedication AdherenceMiddle AgedSocial SupportCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitorsmedication adherencesocial forcesocial supportstatins

Identifiers

PMID27612487
PMCPMC5330995
OpenAlexW2510727859

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.