Evidence map›Paper›PMID 27612382›Full record

ArticleeLife2016

Hedgehog signaling regulates gene expression in planarian glia.

Irving E Wang, Sylvain W Lapan, M Lucila Scimone, Thomas R Clandinin, Peter W Reddien

Open access · goldAbstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Evolution of Oligodendroglia and Myelin.Advances in neurobiology · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. An insight into planarian regeneration.Cell proliferation · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Irving E WangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Sylvain W LapanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
M Lucila ScimoneDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Thomas R ClandininDepartment of Neurobiology, Stanford University, Stanford, United States.ORCID 0000-0001-6277-6849
Peter W ReddienDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-5569-333X
Howard Hughes Medical Institute · USStanford University · US

Funding

Stem cell and regeneration regulatory genes in planariansR01GM080639 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI REDDIEN, PETER · 2008 to 2020
$4.6M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM080639
6 · The paper itself

Abstract

Hedgehog signaling is critical for vertebrate central nervous system (CNS) development, but its role in CNS biology in other organisms is poorly characterized. In the planarian

Indexed as

Gene Expression RegulationPlanariansSignal TransductionAnimalsHedgehog ProteinsNeurogliaHedgehog Proteinsastrocytesdevelopmental biologygliaHedgehog signalingplanariaregenerationSchmidtea mediterraneastem cells

Identifiers

PMID27612382
PMCPMC5055395
OpenAlexW2516927204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.