ArticleNuclear medicine communications2016
The incidence of thyroid cancer in focal hypermetabolic thyroid lesions: an 18F-FDG PET/CT study in more than 6000 patients.
Article in Nuclear medicine communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Focal Thyroid Incidentalomas onFrontiers in endocrinology · 2021Pooled it
- Definitions of Incidental [Diagnostics (Basel, Switzerland) · 2024Review
- [European journal of nuclear medicine and molecular imaging · 2023Article
- Review
- Benefits and harms of implementing [EJNMMI research · 2021Article
- The Role of Metabolic Volumetric Parameters in Predicting Malignancy in Incidental Thyroid Nodules Detected inMolecular imaging and radionuclide therapy · 2021Article
- Characteristics of malignant thyroid lesions on [European journal of radiology open · 2021Article
- The role of histogram analysis of grayscale sonograms to differentiate thyroid nodules identified by 18F-FDG PET-CT.Medicine · 2020Article
- Evaluation of Malignancy Risk in 18F-FDG PET/CT Thyroid Incidentalomas.Diagnostics (Basel, Switzerland) · 2019Article
- Diagnostic Value of FDG PET-CT Quantitative Parameters and Deauville-Like 5 Point-Scale in Predicting Malignancy of Focal Thyroid Incidentaloma.Frontiers in medicine · 2019Article
- Thyroid GlandEuropean thyroid journal · 2018Article
- Evidence-based management of incidental focal uptake of fluorodeoxyglucose on PET-CT.The British journal of radiology · 2018Review
- Clinical significance of patterns of increased [Japanese journal of radiology · 2018Review
- 18F-FDG PET/CT imaging of atypical subacute thyroiditis in thyrotoxicosis: A case report.Medicine · 2017Article
- [European journal of hybrid imaging · 2017Article
- Clinical significance of thyroid incidentalomas detected on fluorodeoxyglucose positron emission tomography scan (PETomas): An Indian experience.World journal of nuclear medicineArticle
- Diagnostic Value of Volume-Based Fluorine-18-Fluorodeoxyglucose PET/CT Parameters for Characterizing Thyroid Incidentaloma.Korean journal of radiologyArticle
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8 authors.
Funding
Abstract
backgroundThe clinical significance of incidental thyroid abnormalities discovered in fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) (FDG PET/CT) studies remains controversial. The aim of this large retrospective study was to (a) determine the prevalence of focal F-FDG thyroid uptake on whole-body F-FDG PET/CT studies carried out for nonthyroid cancers and (b) to test whether intense focal F-FDG thyroid uptake is associated with malignancy. MATERIALS AND
methodsA total of 11 921 F-FDG PET/CT studies in 6216 patients carried out at our institution between January 2012 and December 2014 were analyzed. We retrospectively reviewed the medical records of these patients. Eight hundred and forty-five/6216 (13.6%) patients had a thyroid incidentaloma on the basis of the clinical F-FDG PET/CT report. One hundred and sixty/845 (18.9%) of these underwent ultrasound and 98 (61.3%) of these underwent a fine-needle aspiration (FNA). Twenty-six of these 98 (26.5%) patients underwent thyroidectomy. Thyroid lesion and background standardized uptake value (SUVs) for each patient were measured upon review of the F-FDG PET/CT study. We measured maximum standardized uptake value (SUVmax), thyroid to background TL/TBG, thyroid to bloodpool TL/BP and thyroid to liver TL/L ratios in benign and malignant lesions. Receiver operating curves were calculated to determine optimal cut-off values between malignant and benign lesions.
resultsTwenty-one of the 98 patients who underwent FNA biopsy or thyroidectomy had malignant disease (21.4%). Malignant lesions had significantly higher thyroid lesion SUVmax, TL/TBG, TL/BP, and TL/L than benign nodules. The receiver operating curves derived cut-off ratio TL/TBG of more than 2.0 differentiated benign from malignant lesions best with a specificity and sensitivity of 0.76 and 0.88, respectively.
conclusionThe incidence of malignancy in biopsied focal hypermetabolic thyroid lesions is 21.4%. Lesions on F-FDG PET/CT studies, with a ratio TL/TBG more than 2.0, warrant further work-up with ultrasound and FNA to exclude malignancy.
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