Evidence map›Paper›PMID 27612022›Full record

ArticleGenetic testing and molecular biomarkers2016

Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.

Faranak Madadi, Mahmoud Shekari Khaniani, Ehsan Esmaili Shandiz, Hormoz Ayromlou, Safa Najmi, Babak Emamalizadeh, Shaghayegh Taghavi, Javad Jamshidi, Abbas Tafakhori, Gholam-Ali Shahidi and 1 more

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Article in Genetic testing and molecular biomarkers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Association BetweenFrontiers in neurology · 2019
    Pooled it
  3. Review
  4. Review
  5. The role ofFrontiers in neuroscience · 2024
    Article
  6. Alzheimer's Disease-Associated SNP rs708727 inInternational journal of molecular sciences · 2022
    Article
  7. SNPs rs11240569, rs708727, and rs823156 inInternational journal of molecular sciences · 2019
    Article
  8. Review
  9. Article
  10. Aldehyde Dehydrogenase 2 (ALDH2) Glu504Lys Polymorphism Affects Collateral Circulation and Short-Term Prognosis of Acute Cerebral Infarction Patients.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Faranak Madadi1 Neuroscience Research Center, Tabriz University of Medical Sciences , Tabriz, Iran .
Mahmoud Shekari Khaniani2 Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Ehsan Esmaili Shandiz3 Neurology Department, Ganjavian Hospital, Dezful University of Medical Sciences , Dezful, Iran .
Hormoz Ayromlou4 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Safa Najmi4 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran .
Babak Emamalizadeh5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Shaghayegh Taghavi5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Javad Jamshidi6 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences , Fasa, Iran .
Abbas Tafakhori7 Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences , Tehran, Iran .
Gholam-Ali Shahidi8 Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences , Tehran, Iran .
Hossein Darvish5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Tabriz University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRDezful University of Medical Sciences · IRFasa University of Medical Sciences · IRImam Khomeini Hospital · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsParkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population.

methodsIn a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PD patients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests.

resultsA significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95% CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms.

conclusionThe association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population.

Indexed as

Polymorphism, Single NucleotideAgedAldehyde Dehydrogenase, MitochondrialAnion Exchange Protein 1, ErythrocyteCarrier ProteinsFemaleHumansIranMaleMiddle AgedParkinson DiseaseRisk FactorsAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAnion Exchange Protein 1, ErythrocyteCarrier ProteinsSLC4A1 protein, humanZNF512B protein, human

Identifiers

PMID27612022
PMCPMC7871989
OpenAlexW2518490413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.