ArticleScientific reports2016
Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The health impact of residential retreats: a systematic review.BMC complementary and alternative medicine · 2018Pooled it
- Metabolomics of Aerobic Exercise in Chronic Stroke Survivors: A Pilot Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Immunosenescence and Inflamm-Aging: Clinical Interventions and the Potential for Reversal of Aging.Cureus · 2024Review
- Review
- The Microbiome in Health and Disease from the Perspective of Modern Medicine and Ayurveda.Medicina (Kaunas, Lithuania) · 2020Review
- Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana.Molecular and cellular biochemistry · 2020Article
- What is Evidence-Based Functional Medicine in the 21st Century?Integrative medicine (Encinitas, Calif.) · 2019Article
- Psychosocial Effects of a Holistic Ayurvedic Approach to Well-being in Health and Wellness Courses.Global advances in health and medicine · 2019Article
- Changes in MIDAS, Perceived Stress, Frontalis Muscle Activity and Non-Steroidal Anti-Inflammatory Drugs Usage in Patients with Migraine Headache without Aura following Ayurveda and Yoga Compared to Controls: An Open Labeled Non-Randomized Study.Annals of neurosciences · 2018Article
- Advancing Research on Traditional Whole Systems Medicine Approaches.Journal of evidence-based complementary & alternative medicine · 2017Article
- Do Wellness Tourists Get Well? An Observational Study of Multiple Dimensions of Health and Well-Being After a Week-Long Retreat.Journal of alternative and complementary medicine (New York, N.Y.) · 2017Observational
- Relationships among classifications of ayurvedic medicine diagnostics for imbalances and western measures of psychological states: An exploratory study.Journal of Ayurveda and integrative medicineArticle
- Article
- Efficacy of Integrated Yoga and Ayurveda Rasayana on cognitive functions in elderly with mild cognitive impairment: Non-randomized three-arm clinical trial.Journal of Ayurveda and integrative medicineArticle
- Ayurveda and the science of aging.Journal of Ayurveda and integrative medicineReview
- 5-HTTLPR andIndian journal of psychiatryArticle
- Integrity of Ayurveda.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
Abstract
The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based intervention. In the experimental group, 65 healthy male and female subjects participated in a 6-day Panchakarma-based Ayurvedic intervention which included herbs, vegetarian diet, meditation, yoga, and massage. A set of 12 plasma phosphatidylcholines decreased (adjusted p < 0.01) post-intervention in the experimental (n = 65) compared to control group (n = 54) after Bonferroni correction for multiple testing; within these compounds, the phosphatidylcholine with the greatest decrease in abundance was PC ae C36:4 (delta = -0.34). Application of a 10% FDR revealed an additional 57 metabolites that were differentially abundant between groups. Pathway analysis suggests that the intervention results in changes in metabolites across many pathways such as phospholipid biosynthesis, choline metabolism, and lipoprotein metabolism. The observed plasma metabolomic alterations may reflect a Panchakarma-induced modulation of metabotypes. Panchakarma promoted statistically significant changes in plasma levels of phosphatidylcholines, sphingomyelins and others in just 6 days. Forthcoming studies that integrate metabolomics with genomic, microbiome and physiological parameters may facilitate a broader systems-level understanding and mechanistic insights into these integrative practices that are employed to promote health and well-being.
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