ArticlePloS one2016
Altered Resting-State Functional Connectivity of the Striatum in Parkinson's Disease after Levodopa Administration.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Resting-state motor network connectivity as a biomarker of Levodopa response in Parkinson's disease.Brain imaging and behavior · 2026Review
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Article
- Hippocampal resting-state connectivity is associated with posterior-cortical cognitive impairment in Parkinson's disease.Brain and behavior · 2024Article
- Continuous theta burst stimulation over right cerebellum for speech impairment in Parkinson's disease: study protocol for a randomized, sham-controlled, clinical trial.Frontiers in aging neuroscience · 2023Article
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Structural MRI substrate of long-duration response to levodopa in Parkinson's disease: an exploratory study.Journal of neurology · 2021Article
- The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson's disease.Brain imaging and behavior · 2021Article
- Motor Symptom Lateralization Influences Cortico-Striatal Functional Connectivity in Parkinson's Disease.Frontiers in neurology · 2021Article
- Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders.Schizophrenia bulletin · 2020Article
- Connectome-Based Model Predicts Deep Brain Stimulation Outcome in Parkinson's Disease.Frontiers in computational neuroscience · 2020Article
- Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson's Disease with Mild Cognitive Impairment.Aging and disease · 2019Article
- Functional correlates of strategy formation and verbal suppression in Parkinson's disease.NeuroImage. Clinical · 2019Article
- Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell's Palsy.Frontiers in aging neuroscience · 2019Article
- Interactive effects of dopamine transporter genotype and aging on resting-state functional networks.PloS one · 2019Article
- Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson's disease patients.Scientific reports · 2018Article
- Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson's Disease.Molecular neurobiology · 2018Article
- Neuroimaging and neuropsychological assessment of freezing of gait in Parkinson's disease.Alzheimer's & dementia (New York, N. Y.) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite improvement in motor symptoms, the effect of dopaminergic medications on cognition in patients with Parkinson's disease (PD) is less clear. The purpose of this study was to reveal levodopa-induced acute changes in the functional connectivity of the striatum in patients with PD compared with matched untreated patients and healthy volunteers.
methodsTwenty-two patients with PD underwent functional magnetic resonance imaging both ON and OFF dopamine-replacement therapy on two consecutive days. Twenty-eight normal aging volunteers also did them without taking in levodopa. Three caudate seeds and two putamen seeds were selected to calculate functional connectivity intensity.
resultsMotor symptoms measured by UPDRS were significantly worse in PD OFF than PD ON. Decreased functional connectivity in PD OFF compared to controls was detected in the following seed regions: dorsal caudate, ventral putamen and dorsal putamen. Increases in connectivity in PD ON compared to controls were found in the primary and supplementary motor areas and the associative prefrontal and parietal regions, while decreases in anterior cingulate, ventromedial prefrontal cortex, and parahippocampal gyrus. For the ventral striatal seeds, decreased connectivity in PD ON compared to PD OFF was found in the ventromedial prefrontal and orbitofrontal regions, dorsolateral prefrontal regions. For the dorsal striatal seeds, increased connectivity in PD ON compared to PD OFF was observed in the primary and secondary motor areas.
conclusionOur results suggest that levodopa significantly changes the motor and cognitive networks of the cortico-striatal pathways. This knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy.
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