Evidence map›Paper›PMID 27611948›Full record

ArticleOncotarget2016

Zinc transporters are differentially expressed in human non-small cell lung cancer.

Cuiping Huang, Xiaobo Cui, Xiaotian Sun, Jingxuan Yang, Min Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Metal Ions Within the Neuro-Immune-Tumor Axis.Journal of immunology research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Cuiping HuangDepartment of Internal Medicine, College of Clinical Medicine, Hubei University of Science and Technology, Xianning, Hubei 437100, China.
Xiaobo CuiThe Vivian L. Smith Department of Neurosurgery, the University of Texas Medical School at Houston, Houston, TX 77030, USA.
Xiaotian SunThe Vivian L. Smith Department of Neurosurgery, the University of Texas Medical School at Houston, Houston, TX 77030, USA.
Jingxuan YangThe Vivian L. Smith Department of Neurosurgery, the University of Texas Medical School at Houston, Houston, TX 77030, USA.
Min LiThe Vivian L. Smith Department of Neurosurgery, the University of Texas Medical School at Houston, Houston, TX 77030, USA.
University of Oklahoma Health Sciences Center · USHarbin Medical University · CNHubei University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is one of the most common human malignancies worldwide, but its oncogenesis process remains unclear. Recent studies demonstrated that zinc (Zn) and Zn transporters were associated with the development and progression of human cancers. The role of Zn transporters including ZIPs and ZnTs in lung cancer, however, has never been evaluated. Thus, we aimed to investigate the expression levels of all human Zn transporters, including 14 ZIPs and 10 ZnTs, in eight different lung cancer cell lines and paired human tumor tissues. We observed great variations in ZIPs and ZnTs mRNA levels across cell lines and human lung cancer specimens. ZIPs showed a tendency to be upregulated, while ZnTs exhibited a downward expression trend. ZIP4 was overexpressed in six lung cancer cell lines and 59% (26/44) of tumor tissues, which was consistent with results from lung cancer datasets including TCGA database. Our results indicated that the dysregulation of Zn transporters may contribute to lung tumorigenesis.

Indexed as

Carcinoma, Non-Small-Cell LungCarrier ProteinsCell Line, TumorHumansLung NeoplasmsCarrier Proteinszinc-binding proteinexpression profilinglung cancerzinc transporterZIP4

Identifiers

PMID27611948
PMCPMC5341848
OpenAlexW2510732971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.