ArticlePlant biotechnology journal2017
Aldo-keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants.
Article in Plant biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Thirty years of glyphosate-resistant crops and weeds: Current situation and future prospects.Pest management science · 2026Review
- Diversity of glyphosate-degrading bacteria and degradation genes from Xinjiang cotton field's unique soil environment.Environmental microbiome · 2025Article
- Comparison of Glyphosate-Degradation Ability of Aldo-Keto Reductase (AKR4) Proteins in Maize, Soybean and Rice.International journal of molecular sciences · 2023Article
- Multiple Resistance Mechanisms Involved in Glyphosate Resistance inPlants (Basel, Switzerland) · 2022Article
- Article
- Resistance to a nonselective 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide via novel reduction-dehydration-glutathione conjugation in Amaranthus tuberculatus.The New phytologist · 2021Article
- Article
- Glyphosate: Uses Other Than in Glyphosate-Resistant Crops, Mode of Action, Degradation in Plants, and Effects on Non-target Plants and Agricultural Microbes.Reviews of environmental contamination and toxicology · 2021Article
- Overexpression of improved EPSPS gene results in field level glyphosate tolerance and higher grain yield in rice.Plant biotechnology journal · 2020Article
- Mechanisms of evolved herbicide resistance.The Journal of biological chemistry · 2020Review
- Article
- Analysis of Aldo-Keto Reductase Gene Family and Their Responses to Salt, Drought, and Abscisic Acid Stresses inInternational journal of molecular sciences · 2020Article
- Enhanced Metabolic Degradation: The Last Evolved Glyphosate Resistance Mechanism of Weeds?Plant physiology · 2019Article
- Aldo-keto Reductase Metabolizes Glyphosate and Confers Glyphosate Resistance inPlant physiology · 2019Article
- Integrin targeting of glyphosate and its cell adhesion modulation effects on osteoblastic MC3T3-E1 cells revealed by label-free optical biosensing.Scientific reports · 2018Article
- Co-expression of P173S Mutant RiceFrontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, concerns about the use of glyphosate-resistant crops have increased because of glyphosate residual levels in plants and development of herbicide-resistant weeds. In spite of identifying glyphosate-detoxifying genes from microorganisms, the plant mechanism to detoxify glyphosate has not been studied. We characterized an aldo-keto reductase gene from Pseudomonas (PsAKR1) and rice (OsAKR1) and showed, by docking studies, both PsAKR1 and OsAKR1 can efficiently bind to glyphosate. Silencing AKR1 homologues in rice and Nicotiana benthamiana or mutation of AKR1 in yeast and Arabidopsis showed increased sensitivity to glyphosate. External application of AKR proteins rescued glyphosate-mediated cucumber seedling growth inhibition. Regeneration of tobacco transgenic lines expressing PsAKR1 or OsAKRI on glyphosate suggests that AKR can be used as selectable marker to develop transgenic crops. PsAKR1- or OsAKRI-expressing tobacco and rice transgenic plants showed improved tolerance to glyphosate with reduced accumulation of shikimic acid without affecting the normal photosynthetic rates. These results suggested that AKR1 when overexpressed detoxifies glyphosate in planta.
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