Evidence map›Paper›PMID 27611903›Full record

SynthesisRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias.

Felipe B Schuch, Davy Vancampfort, Simon Rosenbaum, Justin Richards, Philip B Ward, Nicola Veronese, Marco Solmi, Eduardo L Cadore, Brendon Stubbs

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  4. Association between physical activity and patient-reported outcome measures in patients with lung cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Pooled it
  5. Correlation between Handgrip Strength and Depression in Older Adults-A Systematic Review and a Meta-Analysis.International journal of environmental research and public health · 2021
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Felipe B SchuchHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Davy VancampfortDepartment of Rehabilitation Sciences, University of Leuven, Leuven, Belgium.
Simon RosenbaumSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Justin RichardsCharles Perkins Centre, School of Public Health, University of Sydney, Sydney, Australia.
Philip B WardSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Nicola VeroneseGeriatrics Section, Department of Medicine, Università degli Studi di Padova, Padova, Italy.
Marco SolmiULSS 17 Mental Health Department, Department of Neurosciences, Università degli Studi di Padova, Padova, Italy.
Eduardo L CadoreDepartamento de Educação Física, UFRGS, Porto Alegre, RS, Brazil.
Brendon StubbsDepartment of Physiotherapy, South London and Maudsley NHS Foundation Trust, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data.

methodsWe conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted.

resultsEight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities.

conclusionAdjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults.

Indexed as

Randomized Controlled Trials as TopicAgedAged, 80 and overAge FactorsExercise TherapyFemaleHumansMajor Depressive DisorderMaleMiddle AgedPublication BiasRisk FactorsTreatment Outcome

Identifiers

PMID27611903
PMCPMC7194268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.