ArticleAmerican journal of respiratory and critical care medicine2017
Micro-Computed Tomography Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05092035 (Recognition of Early Pulmonary Structural Changes by Using Real-time High Fidelity Expiratory CO2 Analysis), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recognition of Early Pulmonary Structural Changes by Using Real-time High Fidelity Expiratory CO2 Analysis
Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026Article
- From Web to Collapse: Small Airway Disease Trajectory in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2025Article
- Distinct Morphological Types of Small Airway Obstructions in Smokers with Emphysema and End-Stage Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2025Article
- Automated CT-based decoupling of the effects of airway narrowing and wall thinning on airway counts in chronic obstructive pulmonary disease.The British journal of radiology · 2025Article
- A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Article
- Lung development and regeneration: newly defined cell types and progenitor status.Cell regeneration (London, England) · 2023Review
- Morphometric analysis of airways in pre-COPD and mild COPD lungs using continuous surface representations of the bronchial lumen.Frontiers in bioengineering and biotechnology · 2023Article
- Article
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- From Macroscopy to Ultrastructure: An Integrative Approach to Pulmonary Pathology.Frontiers in medicine · 2022Article
- Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction.Medicina (Kaunas, Lithuania) · 2021Observational
- Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases.Diagnostics (Basel, Switzerland) · 2021Review
- Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease.The Korean journal of internal medicine · 2021Review
- Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema.Thorax · 2021Article
- Central airway and peripheral lung structures in airway disease-dominant COPD.ERJ open research · 2021Article
- Observational
- Comprehensive stereological assessment of the human lung using multiresolution computed tomography.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study.The Lancet. Respiratory medicine · 2020Article
- Fractal Analysis of Lung Structure in Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2020Review
- Finally More Direct Evidence That Impulse Oscillometry Measures Small Airway Disease.American journal of respiratory and critical care medicine · 2019Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
Abstract
rationaleVery little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles.
objectivesTo examine the structure of preterminal bronchioles located one generation proximal to terminal bronchioles in centrilobular and panlobular emphysema.
methodsPreterminal bronchioles were identified by backtracking from the terminal bronchioles, and their centerlines were established along the entire length of their lumens. Multiple cross-sectional images perpendicular to the centerline were reconstructed to evaluate the bronchiolar wall and lumen, and the alveolar attachments to the outer airway walls in relation to emphysematous destruction in 28 lung samples from six patients with centrilobular emphysema, 20 lung samples from seven patients with panlobular emphysema associated with alpha-1 antitrypsin deficiency, and 47 samples from seven control (donor) lungs. MEASUREMENTS AND MAIN
resultsThe preterminal bronchiolar length, wall volume, total volume (wall + lumen), lumen circularity, and number of alveolar attachments were reduced in both centrilobular and panlobular emphysema compared with control lungs. In contrast, thickening of the wall and narrowing of the lumen were more severe and heterogeneous in centrilobular than in panlobular emphysema. The bronchiolar lumen was narrower in the middle than at both ends, and the decreased number of alveolar attachments was associated with increased wall thickness in centrilobular emphysema.
conclusionsThese results provide new information about small airways pathology in centrilobular and panlobular emphysema and show that these changes affect airways that are not visible with thoracic multidetector computed tomography scans but located proximal to the terminal bronchioles in chronic obstructive pulmonary disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.