ArticleScientific reports2016
Molecular mechanism of male differentiation is conserved in the SRY-absent mammal, Tokudaia osimensis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Microbiota contributes to regulates the external genitalia development through gut-testis axis in male geese.Poultry science · 2026Article
- The impact of induced pluripotent stem cells in animal conservation.Veterinary research communications · 2024Review
- Chromosomal-level assembly of Tokudaia osimensis, Tokudaia tokunoshimensis, and Tokudaia muenninki genomes.Scientific data · 2023Article
- Turnover of mammal sex chromosomes in theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Sexual dimorphism in brain transcriptomes of Amami spiny rats (Tokudaia osimensis): a rodent species where males lack the Y chromosome.BMC genomics · 2019Article
- Molecular cloning and mRNA expression pattern ofJournal of genetics · 2018Article
- Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases.Molecular medicine reports · 2018Article
- Unique XCI evolution in Tokudaia: initial XCI of the neo-X chromosome in Tokudaia muenninki and function loss of XIST in Tokudaia osimensis.Chromosoma · 2017Article
- Article
- Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nature reviews. Genetics · 2017Review
- Flexible adaptation of male germ cells from female iPSCs of endangeredScience advances · 2017Article
- Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?Frontiers in neuroscience · 2017Review
- AAsian journal of andrologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sex-determining gene SRY induces SOX9 expression in the testes of eutherian mammals via two pathways. SRY binds to testis-specific enhancer of Sox9 (TESCO) with SF1 to activate SOX9 transcription. SRY also up-regulates ER71 expression, and ER71 activates Sox9 transcription. After the initiation of testis differentiation, SOX9 enhances Amh expression by binding to its promoter with SF1. SOX8, SOX9 and SOX10, members of the SOXE gene family, also enhance the activities of the Amh promoter and TESCO. In this study, we investigated the regulation of these sexual differentiation genes in Tokudaia osimensis, which lacks a Y chromosome and the SRY gene. The activity of the AMH promoter was stimulated by SOXE genes and SF1. Mutant AMH promoters, with mutations in its SOX and SF1 binding sites, did not show significant activity by SOX9 and SF1. These results indicate that AMH expression was regulated by the binding of SOX9 and SF1. By contrast, SOXE genes could not enhance TESCO activity. These results indicate that TESCO enhancer activity was lost in this species. Furthermore, the activity of the SOX9 promoter was enhanced by ER71, indicating that ER71 may play an important role in the testis-specific expression of SOX9.
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