Evidence map›Paper›PMID 27611467›Full record

ArticlePloS one2016

Variation in the Dicer and RAN Genes Are Associated with Survival in Patients with Hepatocellular Carcinoma.

Mi Na Kim, Jung Oh Kim, Seung Min Lee, Hana Park, Ju Ho Lee, Kyu Sung Rim, Seong Gyu Hwang, Nam Keun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Association of miRNA biosynthesis genesBioscience reports · 2018
    Pooled it
  3. Impacts ofCurrent issues in molecular biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mi Na KimDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Jung Oh KimInstitute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Seung Min LeeInstitute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Hana ParkDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Ju Ho LeeDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Kyu Sung RimDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Seong Gyu HwangDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Nam Keun KimInstitute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
CHA University Bundang Medical Center · KRCHA University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-nucleotide polymorphisms (SNPs) in microRNA machinery genes might affect microRNA processing and subsequently impact tumorigenesis. The aim of this study was to investigate the associations between SNPs in microRNA machinery genes and hepatocellular carcinoma (HCC) in a Korean population. Genotyping of six SNPs in microRNA machinery genes was performed using blood samples from 147 patients with HCC and 209 healthy control subjects. None of the six SNPs in microRNA machinery genes were significantly associated with HCC development. However, among the models for six polymorphic loci-DICER (rs3742330 and rs13078), DROSHA (rs10719 and rs6877842), RAN (rs14035) and XPO5 (rs11077)-one allele combination (A-A-T-C-C-C) showed synergistic effects in terms of an increased risk of HCC development (odds ratio = 8.881, 95% confidence interval [CI] = 1.889-41.750; P = 0.002). Multivariate Cox proportional hazard regression analysis showed a significant survival benefit for the DICER rs3742330 GG compared with the AA type (hazard ratio [HR], 0.314; 95% CI, 0.135-0.730; P = 0.007) and for the RAN rs14035 CT compared with the CC genotype (HR, 0.587; 95% CI, 0.349-0.987; P = 0.044). Although we found no direct association between DICER (rs3742330 and rs13078), DROSHA (rs10719 and rs6877842), RAN (rs14035) or XPO5 (rs11077) polymorphisms and HCC risk, we demonstrated that DICER (rs3742330) and RAN (rs14035) were associated with the survival of HCC patients. Future studies with larger samples are needed to determine associations of SNPs in microRNA machinery genes with HCC risk and prognosis.

Indexed as

SurvivorsCarcinoma, HepatocellularCase-Control StudiesDEAD-box RNA HelicasesFemaleHaplotypesHumansKaryopherinsLiver NeoplasmsMaleMicroRNAsMiddle AgedPolymorphism, Single NucleotidePrognosisran GTP-Binding ProteinRegression AnalysisDEAD-box RNA HelicasesDICER1 protein, humanDROSHA protein, humanKaryopherinsMicroRNAsran GTP-Binding ProteinRAN protein, humanRibonuclease IIIXPO5 protein, human

Identifiers

PMID27611467
PMCPMC5017754
OpenAlexW2509625422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.